Biodegradable β-tricalcium phosphate cement with anti-washout property based on chelate-setting mechanism of inositol phosphate

Toshiisa Konishi, Shuhei Takahashi, Zhi Zhuang, Kohei Nagata, Minori Mizumoto, Michiyo Honda, Yasuhiro Takeuchi, Hitomi Matsunari, Hiroshi Nagashima, Mamoru Aizawa

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Novel biodegradable β-tricalcium phosphate (β-TCP) cements with anti-washout properties were created on the basis of chelate-setting mechanism of inositol phosphate (IP6) using β-TCP powders. The β-TCP powders were ball-milled using ZrO2 beads for 0-6 h in the IP6 solutions with concentrations from 0 to 10,000 ppm. The chelate-setting β-TCP cement with anti-washout property was successfully fabricated by mixing the β-TCP powder ball-milled in 3,000 ppm IP6 solution for 3 h and 2.5 mass% Na 2HPO4 solution, and compressive strength of the cement was 13.4 ± 0.8 MPa. An in vivo study revealed that the above cement was directly in contact with host and newly formed bones without fibrous tissue layers, and was resorbed by osteoclast-like cells on the surface of the cement. The chelate-setting β-TCP cement with anti-washout property is promising for application as a novel injectable artificial bone with both biodegradability and osteoconductivity.

Original languageEnglish
Pages (from-to)1383-1394
Number of pages12
JournalJournal of Materials Science: Materials in Medicine
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

Fingerprint

Inositol Phosphates
Powders
Cements
Phosphates
Compressive Strength
Bone and Bones
Osteoclasts
Bone
Injections
Biodegradability
Compressive strength
tricalcium phosphate
Tissue

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering

Cite this

Biodegradable β-tricalcium phosphate cement with anti-washout property based on chelate-setting mechanism of inositol phosphate. / Konishi, Toshiisa; Takahashi, Shuhei; Zhuang, Zhi; Nagata, Kohei; Mizumoto, Minori; Honda, Michiyo; Takeuchi, Yasuhiro; Matsunari, Hitomi; Nagashima, Hiroshi; Aizawa, Mamoru.

In: Journal of Materials Science: Materials in Medicine, Vol. 24, No. 6, 06.2013, p. 1383-1394.

Research output: Contribution to journalArticle

Konishi, T, Takahashi, S, Zhuang, Z, Nagata, K, Mizumoto, M, Honda, M, Takeuchi, Y, Matsunari, H, Nagashima, H & Aizawa, M 2013, 'Biodegradable β-tricalcium phosphate cement with anti-washout property based on chelate-setting mechanism of inositol phosphate', Journal of Materials Science: Materials in Medicine, vol. 24, no. 6, pp. 1383-1394. https://doi.org/10.1007/s10856-013-4903-8
Konishi, Toshiisa ; Takahashi, Shuhei ; Zhuang, Zhi ; Nagata, Kohei ; Mizumoto, Minori ; Honda, Michiyo ; Takeuchi, Yasuhiro ; Matsunari, Hitomi ; Nagashima, Hiroshi ; Aizawa, Mamoru. / Biodegradable β-tricalcium phosphate cement with anti-washout property based on chelate-setting mechanism of inositol phosphate. In: Journal of Materials Science: Materials in Medicine. 2013 ; Vol. 24, No. 6. pp. 1383-1394.
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