Biocompatibility of CaSiO3/high-density polyethylene composites prepared by hot-pressing

Miho Tanuma, Yoshikazu Kameshima, Akira Nakajima, Kiyoshi Okada, Shigeo Asai, Masao Sumita

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have reported that CaSiO3 ceramics show very fast bone-like apatite formation in simulated body fluid (SBF). However, CaSiO3 ceramics have disadvantages in their mechanical properties and shapability. It is therefore more effective to develop composites of CaSiO3 particles dispersed in a matrix of polymer or metal. Such composites are usually prepared by homogeneously blending the ceramic powder with the matrix component. This method is, however, ineffective for the preparation of biocompatible polymers or metals because only the surfaces containing accidentally-exposed ceramic particles play a role in generating apatite in SBF. It is therefore necessary to add a large volume of ceramic powder and also to abrade the surface to expose more of the ceramic particles. In this study, CaSiO3/high-density polyethylene (HOPE) composites were prepared by hot-pressing to introduce surface CaSiO3 particles and their biocompatibilities were evaluated under in vitro conditions using SBF. CaSiO3 powders were spread on a HDPE plate and hot-pressed at 140°C and 4.9-14.7 MPa for 2 min. The composite sample (about 10×10×1 mm3 in size) was immersed in 30ml SBF (sample/solution ratio of 2.5 g/1) at 36.5°C. After 14 days soaking, the apatite product particles covered most of the composite surface and formed apatite layers. Bone-like apatite particles were formed only on the surface regions containing exposed CaSiO3 particles but no apatite was formed on the CaSiO3 particles buried in the HDPE matrix. The results show that this surface deposition method is very effective in developing biocompatibility in the composites using very small amounts of CaSiO3 powder (about 3 particles in the surface of the present composites strongly influences their biocompatibility. It will be necessary to improve the homogeneity of CaSiO3 dispersion in the surface of the composites to achieve a more uniform surface apatite layer.

Original languageEnglish
Pages (from-to)1161-1164
Number of pages4
JournalKey Engineering Materials
Volume309-311 II
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

Polyethylene
Hot pressing
High density polyethylenes
Biocompatibility
Apatites
Apatite
Composite materials
Body fluids
Powders
Polymers
Bone
Metals
Mechanical properties

Keywords

  • Biocompatibility
  • CaSiO
  • High-density polyethylene
  • Hot-pressing

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Tanuma, M., Kameshima, Y., Nakajima, A., Okada, K., Asai, S., & Sumita, M. (2006). Biocompatibility of CaSiO3/high-density polyethylene composites prepared by hot-pressing. Key Engineering Materials, 309-311 II, 1161-1164.

Biocompatibility of CaSiO3/high-density polyethylene composites prepared by hot-pressing. / Tanuma, Miho; Kameshima, Yoshikazu; Nakajima, Akira; Okada, Kiyoshi; Asai, Shigeo; Sumita, Masao.

In: Key Engineering Materials, Vol. 309-311 II, 2006, p. 1161-1164.

Research output: Contribution to journalArticle

Tanuma, M, Kameshima, Y, Nakajima, A, Okada, K, Asai, S & Sumita, M 2006, 'Biocompatibility of CaSiO3/high-density polyethylene composites prepared by hot-pressing', Key Engineering Materials, vol. 309-311 II, pp. 1161-1164.
Tanuma, Miho ; Kameshima, Yoshikazu ; Nakajima, Akira ; Okada, Kiyoshi ; Asai, Shigeo ; Sumita, Masao. / Biocompatibility of CaSiO3/high-density polyethylene composites prepared by hot-pressing. In: Key Engineering Materials. 2006 ; Vol. 309-311 II. pp. 1161-1164.
@article{05d023ab08b0409ab4b2f2177528c2d8,
title = "Biocompatibility of CaSiO3/high-density polyethylene composites prepared by hot-pressing",
abstract = "We have reported that CaSiO3 ceramics show very fast bone-like apatite formation in simulated body fluid (SBF). However, CaSiO3 ceramics have disadvantages in their mechanical properties and shapability. It is therefore more effective to develop composites of CaSiO3 particles dispersed in a matrix of polymer or metal. Such composites are usually prepared by homogeneously blending the ceramic powder with the matrix component. This method is, however, ineffective for the preparation of biocompatible polymers or metals because only the surfaces containing accidentally-exposed ceramic particles play a role in generating apatite in SBF. It is therefore necessary to add a large volume of ceramic powder and also to abrade the surface to expose more of the ceramic particles. In this study, CaSiO3/high-density polyethylene (HOPE) composites were prepared by hot-pressing to introduce surface CaSiO3 particles and their biocompatibilities were evaluated under in vitro conditions using SBF. CaSiO3 powders were spread on a HDPE plate and hot-pressed at 140°C and 4.9-14.7 MPa for 2 min. The composite sample (about 10×10×1 mm3 in size) was immersed in 30ml SBF (sample/solution ratio of 2.5 g/1) at 36.5°C. After 14 days soaking, the apatite product particles covered most of the composite surface and formed apatite layers. Bone-like apatite particles were formed only on the surface regions containing exposed CaSiO3 particles but no apatite was formed on the CaSiO3 particles buried in the HDPE matrix. The results show that this surface deposition method is very effective in developing biocompatibility in the composites using very small amounts of CaSiO3 powder (about 3 particles in the surface of the present composites strongly influences their biocompatibility. It will be necessary to improve the homogeneity of CaSiO3 dispersion in the surface of the composites to achieve a more uniform surface apatite layer.",
keywords = "Biocompatibility, CaSiO, High-density polyethylene, Hot-pressing",
author = "Miho Tanuma and Yoshikazu Kameshima and Akira Nakajima and Kiyoshi Okada and Shigeo Asai and Masao Sumita",
year = "2006",
language = "English",
volume = "309-311 II",
pages = "1161--1164",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Biocompatibility of CaSiO3/high-density polyethylene composites prepared by hot-pressing

AU - Tanuma, Miho

AU - Kameshima, Yoshikazu

AU - Nakajima, Akira

AU - Okada, Kiyoshi

AU - Asai, Shigeo

AU - Sumita, Masao

PY - 2006

Y1 - 2006

N2 - We have reported that CaSiO3 ceramics show very fast bone-like apatite formation in simulated body fluid (SBF). However, CaSiO3 ceramics have disadvantages in their mechanical properties and shapability. It is therefore more effective to develop composites of CaSiO3 particles dispersed in a matrix of polymer or metal. Such composites are usually prepared by homogeneously blending the ceramic powder with the matrix component. This method is, however, ineffective for the preparation of biocompatible polymers or metals because only the surfaces containing accidentally-exposed ceramic particles play a role in generating apatite in SBF. It is therefore necessary to add a large volume of ceramic powder and also to abrade the surface to expose more of the ceramic particles. In this study, CaSiO3/high-density polyethylene (HOPE) composites were prepared by hot-pressing to introduce surface CaSiO3 particles and their biocompatibilities were evaluated under in vitro conditions using SBF. CaSiO3 powders were spread on a HDPE plate and hot-pressed at 140°C and 4.9-14.7 MPa for 2 min. The composite sample (about 10×10×1 mm3 in size) was immersed in 30ml SBF (sample/solution ratio of 2.5 g/1) at 36.5°C. After 14 days soaking, the apatite product particles covered most of the composite surface and formed apatite layers. Bone-like apatite particles were formed only on the surface regions containing exposed CaSiO3 particles but no apatite was formed on the CaSiO3 particles buried in the HDPE matrix. The results show that this surface deposition method is very effective in developing biocompatibility in the composites using very small amounts of CaSiO3 powder (about 3 particles in the surface of the present composites strongly influences their biocompatibility. It will be necessary to improve the homogeneity of CaSiO3 dispersion in the surface of the composites to achieve a more uniform surface apatite layer.

AB - We have reported that CaSiO3 ceramics show very fast bone-like apatite formation in simulated body fluid (SBF). However, CaSiO3 ceramics have disadvantages in their mechanical properties and shapability. It is therefore more effective to develop composites of CaSiO3 particles dispersed in a matrix of polymer or metal. Such composites are usually prepared by homogeneously blending the ceramic powder with the matrix component. This method is, however, ineffective for the preparation of biocompatible polymers or metals because only the surfaces containing accidentally-exposed ceramic particles play a role in generating apatite in SBF. It is therefore necessary to add a large volume of ceramic powder and also to abrade the surface to expose more of the ceramic particles. In this study, CaSiO3/high-density polyethylene (HOPE) composites were prepared by hot-pressing to introduce surface CaSiO3 particles and their biocompatibilities were evaluated under in vitro conditions using SBF. CaSiO3 powders were spread on a HDPE plate and hot-pressed at 140°C and 4.9-14.7 MPa for 2 min. The composite sample (about 10×10×1 mm3 in size) was immersed in 30ml SBF (sample/solution ratio of 2.5 g/1) at 36.5°C. After 14 days soaking, the apatite product particles covered most of the composite surface and formed apatite layers. Bone-like apatite particles were formed only on the surface regions containing exposed CaSiO3 particles but no apatite was formed on the CaSiO3 particles buried in the HDPE matrix. The results show that this surface deposition method is very effective in developing biocompatibility in the composites using very small amounts of CaSiO3 powder (about 3 particles in the surface of the present composites strongly influences their biocompatibility. It will be necessary to improve the homogeneity of CaSiO3 dispersion in the surface of the composites to achieve a more uniform surface apatite layer.

KW - Biocompatibility

KW - CaSiO

KW - High-density polyethylene

KW - Hot-pressing

UR - http://www.scopus.com/inward/record.url?scp=33645370751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645370751&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33645370751

VL - 309-311 II

SP - 1161

EP - 1164

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -