Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy

Kiyonori Yamaoka, Fumihiro Mitsunobu, Katsumi Hanamoto, Koichi Shibuya, Shuji Mori, Yoshiro Tanizaki, Katsuhiko Sugita

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52 Citations (Scopus)


The radioactive and thermal effects of radon hot spring were biochemically compared under a sauna room or hot spring conditions with a similar chemical component, using the parameters that are closely involved in the clinic for radon therapy. The results showed that the radon and thermal therapy enhanced the antioxidation functions, such as the activities of superoxide dismutase (SOD) and catalase, which inhibit lipid peroxidation and total cholesterol produced in the body. Moreover the therapy enhanced concanavalin A (ConA)-induced mitogen response and increased the percentage of CD4 positive cells, which is the marker of helper T cells, and decreased the percentage of CD8 positive cells, which is the common marker of killer T cells and suppressor T cells, in the white blood cell differentiation antigen (CD8/CD4) assay. Furthermore, the therapy increased the levels of α atrial natriuretic polypeptide (αANP), β endorphin, adrenocorticotropic hormone (ACTH), insulin and glucose-6-phosphate dehydrogenase (G-6-PDH), and it decreased the vasopression level. The results were on the whole larger in the radon group than in the thermal group. The findings suggest that radon therapy contributes more to the prevention of life-style-related diseases related to peroxidation reactions and immune suppression than to thermal therapy. Moreover, these indicate what may be a part of the mechanism for the alleviation of hypertension, osteoarthritis (pain), and diabetes mellitus brought about more by radon therapy than by thermal therapy.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalJournal of radiation research
Issue number1
Publication statusPublished - Mar 2004


  • Antioxidant
  • Immunity
  • Radon effect
  • Radon therapy
  • Thermal effect

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis


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