TY - JOUR
T1 - Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure
AU - Tsujimoto, Masafumi
AU - Goto, Yoshikuni
AU - Maruyama, Masato
AU - Hattori, Akira
N1 - Funding Information:
Our works described in this review were supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a grant for ‘‘Chemical Biology Research Program’’ from RIKEN.
PY - 2008/9
Y1 - 2008/9
N2 - It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.
AB - It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.
KW - Adipocyte-derived leucine aminopeptidase (A-LAP)
KW - Aminopeptidase A (APA)
KW - M1 family
KW - Placental leucine aminopeptidase (P-LAP)
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U2 - 10.1007/s10741-007-9064-8
DO - 10.1007/s10741-007-9064-8
M3 - Review article
C2 - 17999179
AN - SCOPUS:42049084471
VL - 13
SP - 285
EP - 291
JO - Heart Failure Reviews
JF - Heart Failure Reviews
SN - 1382-4147
IS - 3
ER -