Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

Masafumi Tsujimoto, Yoshikuni Goto, Masato Maruyama, Akira Hattori

Research output: Contribution to journalReview articlepeer-review

41 Citations (Scopus)

Abstract

It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalHeart Failure Reviews
Volume13
Issue number3
DOIs
Publication statusPublished - Sep 1 2008
Externally publishedYes

Keywords

  • Adipocyte-derived leucine aminopeptidase (A-LAP)
  • Aminopeptidase A (APA)
  • M1 family
  • Placental leucine aminopeptidase (P-LAP)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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