Abstract
It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.
| Original language | English |
|---|---|
| Pages (from-to) | 285-291 |
| Number of pages | 7 |
| Journal | Heart Failure Reviews |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 1 2008 |
| Externally published | Yes |
Keywords
- Adipocyte-derived leucine aminopeptidase (A-LAP)
- Aminopeptidase A (APA)
- M1 family
- Placental leucine aminopeptidase (P-LAP)
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Cite this
Tsujimoto, M., Goto, Y., Maruyama, M., & Hattori, A. (2008). Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure. Heart Failure Reviews, 13(3), 285-291. https://doi.org/10.1007/s10741-007-9064-8