Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

Masafumi Tsujimoto; Yoshikuni Goto; Masato Maruyama; Akira Hattori

doi:10.1007/s10741-007-9064-8

Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

Masafumi Tsujimoto, Yoshikuni Goto, Masato Maruyama, Akira Hattori

Research output: Contribution to journal › Review article › peer-review

43 Citations (Scopus)

Abstract

It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)₁₈E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.

Original language	English
Pages (from-to)	285-291
Number of pages	7
Journal	Heart Failure Reviews
Volume	13
Issue number	3
DOIs	https://doi.org/10.1007/s10741-007-9064-8
Publication status	Published - Sep 2008
Externally published	Yes

Keywords

Adipocyte-derived leucine aminopeptidase (A-LAP)
Aminopeptidase A (APA)
M1 family
Placental leucine aminopeptidase (P-LAP)

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure",

abstract = "It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.",

keywords = "Adipocyte-derived leucine aminopeptidase (A-LAP), Aminopeptidase A (APA), M1 family, Placental leucine aminopeptidase (P-LAP)",

author = "Masafumi Tsujimoto and Yoshikuni Goto and Masato Maruyama and Akira Hattori",

note = "Funding Information: Our works described in this review were supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a grant for {\textquoteleft}{\textquoteleft}Chemical Biology Research Program{\textquoteright}{\textquoteright} from RIKEN.",

year = "2008",

month = sep,

doi = "10.1007/s10741-007-9064-8",

language = "English",

volume = "13",

pages = "285--291",

journal = "Heart Failure Reviews",

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T1 - Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

AU - Tsujimoto, Masafumi

AU - Goto, Yoshikuni

AU - Maruyama, Masato

AU - Hattori, Akira

N1 - Funding Information: Our works described in this review were supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a grant for ‘‘Chemical Biology Research Program’’ from RIKEN.

PY - 2008/9

Y1 - 2008/9

N2 - It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.

AB - It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.

KW - Adipocyte-derived leucine aminopeptidase (A-LAP)

KW - Aminopeptidase A (APA)

KW - M1 family

KW - Placental leucine aminopeptidase (P-LAP)

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JO - Heart Failure Reviews

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SN - 1382-4147

IS - 3

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Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

Abstract

Keywords

ASJC Scopus subject areas

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