It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.
- Adipocyte-derived leucine aminopeptidase (A-LAP)
- Aminopeptidase A (APA)
- M1 family
- Placental leucine aminopeptidase (P-LAP)
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine