Bioactivity of CaSiO3/poly-lactic acid (PLA) composites prepared by various surface loading methods of CaSiO3 powder

Kiyoshi Okada, Fumikazu Hasegawa, Yoshikazu Kameshima, Akira Nakajima

Research output: Contribution to journalArticle

Abstract

Mixing bioactive ceramic powders with polymers is an effective method for generating bioactivity to the polymer-matrix composites but it is necessary to incorporate up to 40 vol% of bioactive ceramic powder. However, such a high mixing ratio offsets the advantages of the flexibility and formability of polymer matrix and it would be highly advantageous to lower the mixing ratio. Since surface loading of ceramic powders in the polymer is thought to be an effective way of reducing the mixing ratio of the ceramic powder while maintaining bioactive activity, CaSiO3/poly-lactic acid (PLA) composites were prepared by three methods; (1) casting, (2) spin coating and (3) hot pressing. In methods (1) and (2), a suspension was prepared by dissolving PLA in chloroform and dispersing CaSiO3 powder in it. The suspension was cast and dried to form a film in the case of method (1) while it was spin-coated on a PLA substrate in method (2). In method (3), CaSiO3 powder was surface loaded on to a PLA substrate by hot pressing. The bioactivity of these samples was investigated in vitro using simulated body fluid (SBF). Apatite formation was not observed in the samples prepared by method (1) but some apatite formation was achieved by mixing polyethylene glycol (PEG) with the PLA, producing a porous polymer matrix. In method (2), apatite was clearly observed after soaking for 7 days. Enhanced apatite formation was observed in method (3), the thickness of the resulting apatite layers becoming about 20 μm after soaking for 14 days. Since the amount of CaSiO3 powder used in these samples was only ≤0.4 vol%, it is concluded that this preparation method is very effective in generating bioactivity in polymer-matrix composites by loading with only very small amounts of ceramic powder.

Original languageEnglish
Pages (from-to)899-907
Number of pages9
JournalJournal of Materials Science: Materials in Medicine
Volume18
Issue number5
DOIs
Publication statusPublished - May 2007
Externally publishedYes

Fingerprint

Lactic acid
Bioactivity
Powders
Apatites
Apatite
Composite materials
Ceramics
Polymers
Polymer matrix composites
Hot pressing
Polymer matrix
Suspensions
poly(lactic acid)
Body fluids
Spin coating
Substrates
Formability
Chloroform
Chlorine compounds
Polyethylene glycols

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Chemical Engineering(all)

Cite this

Bioactivity of CaSiO3/poly-lactic acid (PLA) composites prepared by various surface loading methods of CaSiO3 powder. / Okada, Kiyoshi; Hasegawa, Fumikazu; Kameshima, Yoshikazu; Nakajima, Akira.

In: Journal of Materials Science: Materials in Medicine, Vol. 18, No. 5, 05.2007, p. 899-907.

Research output: Contribution to journalArticle

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