Bilirubin adsorption property of sol-gel-derived titania particles for blood purification therapy

Takuji Asano, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Titania (anatase) gel powders were prepared by peptizing commercially available titania sols and heating them at temperatures up to 700 °C, as candidates for bilirubin adsorbents for blood purification therapy. Those titania particles were in contact with a protein solution containing bilirubin and bovine serum albumin that mimics the blood of bilirubinemia patients. The amount of free or direct bilirubin in the solution insignificant. Indirect bilirubin or a bilirubin complex with albumin was adsorbed on the anatase powders, the primary particle size of which was as large as or larger than the size of an albumin molecule. The surface charge and surface charge density were only minor factors in controlling the indirect bilirubin adsorption. The present results indicated that the size of primary particles and hydrophobicity were significant for the sol-derived anatase in terms of bilirubin adsorption, and both were controllable by the heating temperature and the time period.

Original languageEnglish
Pages (from-to)1067-1072
Number of pages6
JournalActa Biomaterialia
Volume4
Issue number4
DOIs
Publication statusPublished - Jul 1 2008

Keywords

  • Adsorption
  • Bilirubin
  • Crystallite size
  • Sol-gel
  • Titania

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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