Bile pigments in emergency and critical care medicine

Mizuki Seya, Toshiyuki Aokage, Tsuyoshi Nojima, Atsunori Nakao, Hiromichi Naito

Research output: Contribution to journalReview articlepeer-review

Abstract

Bile pigments, such as bilirubin and biliverdin, are end products of the heme degradation pathway in mammals and are widely known for their cytotoxic effects. However, recent studies have revealed that they exert cytoprotective effects through antioxidative, anti-inflammatory, and immunosuppressive properties. All these mechanisms are indispensable in the treatment of diseases in the field of emergency and critical care medicine, such as coronary ischemia, stroke, encephalomyelitis, acute lung injury/acute respiratory distress syndrome, mesenteric ischemia, and sepsis. While further research is required before the safe application of bile pigments in the clinical setting, their underlying mechanisms shed light on their utilization as therapeutic agents in the field of emergency and critical care medicine. This article aims to summarize the current understanding of bile pigments and re-evaluate their therapeutic potential in the diseases listed above.

Original languageEnglish
Article number224
JournalEuropean journal of medical research
Volume27
Issue number1
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Antioxidant therapy
  • Bile pigments
  • Emergency and critical care medicine

ASJC Scopus subject areas

  • Medicine(all)

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