Bilateral conjunctival lesions in blastic plasmacytoid dendritic cell neoplasm.

Toshihiko Matsuo, Kouichi Ichimura, Takehiro Tanaka, Shin Morizane, Keiji Iwatsuki, Motoharu Eguchi, Tadashi Yoshino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study is to report on a patient who developed conjunctival lesions of blastic plasmacytoid dendritic cell neoplasm (BPDCN) after radiation to skin lesions of the same pathological type. A 79-year-old man developed salmon-pink lesions in the lower fornix of the conjunctiva of both eyes and biopsy revealed BPDCN. One and a half years previously, he noticed an erythematous plaque with a 30-mm diameter, which later became multiple, on the left chest, and the biopsy revealed BPDCN. The bone marrow was negative for CD56-positive cells, but fluorescence-activated cell sorting analysis of peripheral blood cells revealed a group of cells positive for CD4 and CD56, or CD4 and CD123. The monocyte fraction, in an increased percentage of white blood cell counts, did contain atypical cells positive for the three markers. Whole-body 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography combined with computed tomography demonstrated no abnormal uptake lesions. He received 30 Gy of radiation to the chest lesions, and later, the same dose of radiation to novel skin lesions on the back, waist, and chest, and also to pharyngeal lesions. In conclusion, the conjunctiva could be involved with BPDCN and pathological differential diagnosis by biopsy is mandatory to establish the correct diagnosis.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalJournal of clinical and experimental hematopathology : JCEH
Volume51
Issue number1
DOIs
Publication statusPublished - 2011

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Dendritic Cells
Thorax
Conjunctiva
Biopsy
Neoplasms
Radiation
Radiation Dosage
Skin
Salmon
Deoxyglucose
Leukocyte Count
Positron-Emission Tomography
Monocytes
Blood Cells
Flow Cytometry
Differential Diagnosis
Bone Marrow
Tomography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bilateral conjunctival lesions in blastic plasmacytoid dendritic cell neoplasm. / Matsuo, Toshihiko; Ichimura, Kouichi; Tanaka, Takehiro; Morizane, Shin; Iwatsuki, Keiji; Eguchi, Motoharu; Yoshino, Tadashi.

In: Journal of clinical and experimental hematopathology : JCEH, Vol. 51, No. 1, 2011, p. 49-55.

Research output: Contribution to journalArticle

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