BIG-2 Mediates Olfactory Axon Convergence to Target Glomeruli

Tomomi Kaneko-Goto, Sei ichi Yoshihara, Haruko Miyazaki, Yoshihiro Yoshihara

Research output: Contribution to journalArticlepeer-review

116 Citations (Scopus)

Abstract

Olfactory sensory neurons expressing a given odorant receptor converge axons onto a few topographically fixed glomeruli in the olfactory bulb, leading to establishment of the odor map. Here, we report that BIG-2/contactin-4, an axonal glycoprotein belonging to the immunoglobulin superfamily, is expressed in a subpopulation of mouse olfactory sensory neurons. A mosaic pattern of glomerular arrangement is observed with strongly BIG-2-positive, weakly positive, and negative axon terminals in the olfactory bulb, which is overlapping but not identical with those of Kirrel2 and ephrin-A5. There is a close correlation between the BIG-2 expression level and the odorant receptor choice in individual sensory neurons. In BIG-2-deficient mice, olfactory sensory neurons expressing a given odorant receptor frequently innervate multiple glomeruli at ectopic locations. These results suggest that BIG-2 is one of the axon guidance molecules crucial for the formation and maintenance of functional odor map in the olfactory bulb.

Original languageEnglish
Pages (from-to)834-846
Number of pages13
JournalNeuron
Volume57
Issue number6
DOIs
Publication statusPublished - Mar 27 2008
Externally publishedYes

Keywords

  • MOLNEURO
  • SIGNALING
  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'BIG-2 Mediates Olfactory Axon Convergence to Target Glomeruli'. Together they form a unique fingerprint.

Cite this