Better speech performance in cochlear implant patients with GJB2-related deafness

Kunihiro Fukushima, Kennichi Sugata, Norio Kasai, Shouichirou Fukuda, Rie Nagayasu, Naomi Toida, Nobuhiko Kimura, Teruaki Takishita, Mehmet Gunduz, Kazunori Nishizaki

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Objective: We applied mutation screening in seven cochlear implant users to identify those persons with GJB2-related deafness to determine whether etiology of deafness was predictive of speech performance after implantation. Methods: Direct sequence of GJB2 was conducted over seven cochlear implant users with prelingual hearing impairment and their speech, language and cognitive performance was examined. Results: The three persons with GJB2-related deafness had a mean vocabulary of 1243 words compared to a mean vocabulary of 195 words in the four children with GJB2-unrelated deafness, although the number of patients examined here was limited. The developmental quotient (DQ) of cognitive ability also was higher in those children with GJB2-related deafness. Conclusions: These preliminary results suggest that better speech performance after cochlear implantation may be observed in persons with GJB2-related deafness. In the future, detailed phenotypic studies and mutation screening for non-syndromic hearing loss may play an important role in the preoperative assessment of prelingually-deafened children.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume62
Issue number2
DOIs
Publication statusPublished - Feb 1 2002

Fingerprint

Cochlear Implants
Deafness
Vocabulary
Hearing Loss
Cochlear Implantation
Mutation
Aptitude
Language

Keywords

  • Cochlear implantation
  • Connexin 26
  • GJB2
  • Language development
  • Mutation screening
  • Speech perception

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Better speech performance in cochlear implant patients with GJB2-related deafness. / Fukushima, Kunihiro; Sugata, Kennichi; Kasai, Norio; Fukuda, Shouichirou; Nagayasu, Rie; Toida, Naomi; Kimura, Nobuhiko; Takishita, Teruaki; Gunduz, Mehmet; Nishizaki, Kazunori.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 62, No. 2, 01.02.2002, p. 151-157.

Research output: Contribution to journalArticle

Fukushima, K, Sugata, K, Kasai, N, Fukuda, S, Nagayasu, R, Toida, N, Kimura, N, Takishita, T, Gunduz, M & Nishizaki, K 2002, 'Better speech performance in cochlear implant patients with GJB2-related deafness', International Journal of Pediatric Otorhinolaryngology, vol. 62, no. 2, pp. 151-157. https://doi.org/10.1016/S0165-5876(01)00619-X
Fukushima, Kunihiro ; Sugata, Kennichi ; Kasai, Norio ; Fukuda, Shouichirou ; Nagayasu, Rie ; Toida, Naomi ; Kimura, Nobuhiko ; Takishita, Teruaki ; Gunduz, Mehmet ; Nishizaki, Kazunori. / Better speech performance in cochlear implant patients with GJB2-related deafness. In: International Journal of Pediatric Otorhinolaryngology. 2002 ; Vol. 62, No. 2. pp. 151-157.
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