Beta-2-glycoprotein I and urinary trypsin inhibitor levels in the plasma of pregnant and postpartum women

Junko Masuda, Kimihiro Suzuki, Ayano Satoh, Kyoko Kojima-Aikawa, Kuniaki Nakanishi, Koichi Kuroda, Mitsutaka Murakami, Eiji Takayama, Isamu Matsumoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Annexins (Anx) are a family of structurally related proteins that all bind to anionic phospholipids in a Ca2+-dependent manner. Some biological properties of beta-2-glycoprotein I (β2-GPI) are similar to those of Anx IV and Anx V. Urinary trypsin inhibitor (UTI) helps to maintain normal pregnancy and prevent preterm delivery by inhibiting uterine contraction. However, plasma β2-GPI and UTI levels have not been measured in normal pregnancy. The aim of this study is to clarify the levels of these parameters. Subjects were nonpregnant women (n = 50), 120 pregnant women, and maternal subjects just after delivery (n = 53) or postpartum (n = 67). All of the subjects were healthy. Plasma levels of β2-GPI, UTI, Anx IV, Anx V and other coagulation and fibrinolysis markers were measured by ELISA. The mean plasma level of β2-GPI was significantly increased during the third trimester of pregnancy and 3 to 5 days after delivery. The mean plasma level of UTI was unchanged from the first trimester of pregnancy to the postpartum period. The mean plasma UTI level in vaginal delivery group was significantly higher than that in cesarean section group. β2-GPI protein was expressed in some of the syncytiotrophoblasts. These data suggest that β2-GPI might act to prevent blood clotting on the placental surfaces and also prevents disseminated intravascular coagulation in the microcirculation and maternal plasma. UTI levels might be kept constant by increased urinary excretion despite overproduction during pregnancy.

Original languageEnglish
Pages (from-to)255-261
Number of pages7
JournalThrombosis Research
Volume117
Issue number3
DOIs
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

beta 2-Glycoprotein I
Postpartum Period
Pregnant Women
Glycoproteins
Annexin A4
Annexin A5
Pregnancy
Mothers
Annexins
Uterine Contraction
Disseminated Intravascular Coagulation
Trophoblasts
Third Pregnancy Trimester
Blood Coagulation
Fibrinolysis
First Pregnancy Trimester
Microcirculation
Cesarean Section
urinastatin
Phospholipids

Keywords

  • β-glycoprotein I
  • Annexin
  • Disseminated intravascular coagulation
  • Pregnancy
  • Thrombosis
  • Urinary trypsin inhibitor (Bikunin)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Beta-2-glycoprotein I and urinary trypsin inhibitor levels in the plasma of pregnant and postpartum women. / Masuda, Junko; Suzuki, Kimihiro; Satoh, Ayano; Kojima-Aikawa, Kyoko; Nakanishi, Kuniaki; Kuroda, Koichi; Murakami, Mitsutaka; Takayama, Eiji; Matsumoto, Isamu.

In: Thrombosis Research, Vol. 117, No. 3, 2006, p. 255-261.

Research output: Contribution to journalArticle

Masuda, J, Suzuki, K, Satoh, A, Kojima-Aikawa, K, Nakanishi, K, Kuroda, K, Murakami, M, Takayama, E & Matsumoto, I 2006, 'Beta-2-glycoprotein I and urinary trypsin inhibitor levels in the plasma of pregnant and postpartum women', Thrombosis Research, vol. 117, no. 3, pp. 255-261. https://doi.org/10.1016/j.thromres.2005.03.026
Masuda, Junko ; Suzuki, Kimihiro ; Satoh, Ayano ; Kojima-Aikawa, Kyoko ; Nakanishi, Kuniaki ; Kuroda, Koichi ; Murakami, Mitsutaka ; Takayama, Eiji ; Matsumoto, Isamu. / Beta-2-glycoprotein I and urinary trypsin inhibitor levels in the plasma of pregnant and postpartum women. In: Thrombosis Research. 2006 ; Vol. 117, No. 3. pp. 255-261.
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