Beraprost sodium enhances neovascularization in ischemic myocardium by mobilizing bone marrow cells in rats

Yoshinori Miyahara, Shunsuke Ohnishi, Hiroaki Obata, Kozo Ishino, Shunji Sano, Hidezo Mori, Kenji Kangawa, Soichiro Kitamura, Noritoshi Nagaya

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Beraprost sodium, an orally active prostacyclin analogue, has vasoprotective effects such as vasodilation and antiplatelet activities. We investigated the therapeutic potential of beraprost for myocardial ischemia. Immediately after coronary ligation of Sprague-Dawley rats, beraprost (200 μg/kg/day) or saline was subcutaneously administered for 28 days. Four weeks after coronary ligation, administration of beraprost increased capillary density in ischemic myocardium, decreased infarct size, and improved cardiac function in rats with myocardial infarction. Beraprost markedly increased the number of CD34-positive cells and c-kit-positive cells in plasma. Also, four weeks after coronary ligation of chimeric rats with GFP-expressing bone marrow, bone marrow-derived cells were incorporated into the infarcted region and its border zone. Treatment with beraprost increased the number of GFP/von Willebrand factor-double-positive cells in the ischemic myocardium. These results suggest that beraprost has beneficial effects on ischemic myocardium partly by its ability to enhance neovascularization in ischemic myocardium by mobilizing bone marrow cells.

Original languageEnglish
Pages (from-to)1242-1249
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume349
Issue number4
DOIs
Publication statusPublished - Nov 3 2006

Keywords

  • Bone marrow mobilization
  • Myocardial infarction
  • Neovascularization
  • Prostacyclin analogue

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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