Benzyl isothiocyanate inhibits oxidative stress in mouse skin: Involvement of attenuation of leukocyte infiltration

Yoshimasa Nakamura, Noriyuki Miyoshi, Satoko Takabayashi, Toshihiko Osawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The exposure of benzyl isothiocyanate (BITC) to mouse skin resulted in the attenuation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative damage through not only inhibition of the NADPH oxidase system but also leukocyte clearance at inflamed region. In spite of little ability to affect TPA-induced edema formation, pretreatments of mouse skin with BITC before the first or second TPA treatment significantly decrease the H_2O_2 level. A histological study also demonstrated that BITC enhanced the terminal deoxynucleotidyl transferase-dUTP nick end labeling (TUNEL)-positive index in mouse skin, suggesting that BITC might accelerate the disappearance of infiltrated leukocytes. Thus, these gathered data further supported that BITC has a potential as an anti-inflammatory agent.

Original languageEnglish
Pages (from-to)255-257
Number of pages3
JournalBioFactors
Volume21
Issue number1-4
DOIs
Publication statusPublished - Jan 1 2004
Externally publishedYes

Keywords

  • Benzyl isothiocyanate
  • NADPH oxidase
  • Neutrophil
  • Reactive oxygen species
  • Tumor promotion

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

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