Abstract
An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium iono-phore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogenactivated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.
| Original language | English |
|---|---|
| Pages (from-to) | 159-163 |
| Number of pages | 5 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 79 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 |
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Keywords
- Benzyl isothiocyanate; interleukin-13(IL-13)
- Mitogen-activated protein kinase (MAPK)
- Nuclear factor of activated T cells c1 (NFATc1)
- Nuclear factor-κB (NF-κB)
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Biology
- Applied Microbiology and Biotechnology
- Analytical Chemistry
- Organic Chemistry
- Medicine(all)
Cite this
Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells. / Tang, Yue; Abe, Naomi; Yoshimoto, Motoko; Zhu, Beiwei; Murata, Yoshiyuki; Nakamura, Yoshimasa.
In: Bioscience, Biotechnology and Biochemistry, Vol. 79, No. 1, 2015, p. 159-163.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells
AU - Tang, Yue
AU - Abe, Naomi
AU - Yoshimoto, Motoko
AU - Zhu, Beiwei
AU - Murata, Yoshiyuki
AU - Nakamura, Yoshimasa
PY - 2015
Y1 - 2015
N2 - An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium iono-phore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogenactivated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.
AB - An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium iono-phore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogenactivated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.
KW - Benzyl isothiocyanate; interleukin-13(IL-13)
KW - Mitogen-activated protein kinase (MAPK)
KW - Nuclear factor of activated T cells c1 (NFATc1)
KW - Nuclear factor-κB (NF-κB)
UR - http://www.scopus.com/inward/record.url?scp=84924533871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924533871&partnerID=8YFLogxK
U2 - 10.1080/09168451.2014.963503
DO - 10.1080/09168451.2014.963503
M3 - Article
C2 - 25253661
AN - SCOPUS:84924533871
VL - 79
SP - 159
EP - 163
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 1
ER -