TY - JOUR
T1 - Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells
AU - Tang, Yue
AU - Abe, Naomi
AU - Yoshimoto, Motoko
AU - Zhu, Beiwei
AU - Murata, Yoshiyuki
AU - Nakamura, Yoshimasa
N1 - Funding Information:
This study was supported by MEXT KAKENHI [grant number 25292073 (YN)] and JSPS KAKENHI [grant number 25·46 (NA)].
Publisher Copyright:
© 2014 Japan Society for Bioscience Biotechnology and Agrochemistry.
PY - 2015
Y1 - 2015
N2 - An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium iono-phore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogenactivated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.
AB - An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium iono-phore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogenactivated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.
KW - Benzyl isothiocyanate; interleukin-13(IL-13)
KW - Mitogen-activated protein kinase (MAPK)
KW - Nuclear factor of activated T cells c1 (NFATc1)
KW - Nuclear factor-κB (NF-κB)
UR - http://www.scopus.com/inward/record.url?scp=84924533871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924533871&partnerID=8YFLogxK
U2 - 10.1080/09168451.2014.963503
DO - 10.1080/09168451.2014.963503
M3 - Article
C2 - 25253661
AN - SCOPUS:84924533871
VL - 79
SP - 159
EP - 163
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 1
ER -