Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells

Yue Tang, Naomi Abe, Motoko Yoshimoto, Beiwei Zhu, Yoshiyuki Murata, Yoshimasa Nakamura

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium iono-phore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogenactivated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume79
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • Benzyl isothiocyanate; interleukin-13(IL-13)
  • Mitogen-activated protein kinase (MAPK)
  • Nuclear factor of activated T cells c1 (NFATc1)
  • Nuclear factor-κB (NF-κB)

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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