Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells

Yue Tang; Naomi Abe; Motoko Yoshimoto; Beiwei Zhu; Yoshiyuki Murata; Yoshimasa Nakamura

doi:10.1080/09168451.2014.963503

Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells

Yue Tang, Naomi Abe, Motoko Yoshimoto, Beiwei Zhu, Yoshiyuki Murata, Yoshimasa Nakamura

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium iono-phore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogenactivated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.

Original language	English
Pages (from-to)	159-163
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	79
Issue number	1
DOIs	https://doi.org/10.1080/09168451.2014.963503
Publication status	Published - 2015

Keywords

Benzyl isothiocyanate; interleukin-13(IL-13)
Mitogen-activated protein kinase (MAPK)
Nuclear factor of activated T cells c1 (NFATc1)
Nuclear factor-κB (NF-κB)

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells",

abstract = "An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium iono-phore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogenactivated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.",

keywords = "Benzyl isothiocyanate; interleukin-13(IL-13), Mitogen-activated protein kinase (MAPK), Nuclear factor of activated T cells c1 (NFATc1), Nuclear factor-κB (NF-κB)",

author = "Yue Tang and Naomi Abe and Motoko Yoshimoto and Beiwei Zhu and Yoshiyuki Murata and Yoshimasa Nakamura",

note = "Funding Information: This study was supported by MEXT KAKENHI [grant number 25292073 (YN)] and JSPS KAKENHI [grant number 25·46 (NA)].",

year = "2015",

doi = "10.1080/09168451.2014.963503",

language = "English",

volume = "79",

pages = "159--163",

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T1 - Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells

AU - Tang, Yue

AU - Abe, Naomi

AU - Yoshimoto, Motoko

AU - Zhu, Beiwei

AU - Murata, Yoshiyuki

AU - Nakamura, Yoshimasa

N1 - Funding Information: This study was supported by MEXT KAKENHI [grant number 25292073 (YN)] and JSPS KAKENHI [grant number 25·46 (NA)].

PY - 2015

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KW - Benzyl isothiocyanate; interleukin-13(IL-13)

KW - Mitogen-activated protein kinase (MAPK)

KW - Nuclear factor of activated T cells c1 (NFATc1)

KW - Nuclear factor-κB (NF-κB)

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