Benign lymphoplasia of the earlobes induced by gold earrings: Immunohistologic study on the cellular infiltrates

Keiji Iwatsuki, Mizuho Yamada, Masahiro Takigawa, Kunio Inoue, Kichiro Matsumoto

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We report three patients with peculiar nodules of the earlobes that developed a few months after the wearing of pierced-type gold earrings. Biopsy specimens showed dense infiltration of lymphoid cells in the dermis and subcutaneous tissue associated with the formation of lymphoid follicles. The clinical and histologic pictures were similar to those of lymphocytoma cutis. Immunohistologically, the nodular lesions were characterized by the proliferation of T cells, mainly suppressor/cytotoxic T cells, and the presence of histiocytic cells displaying Leu-3a antigens on the surface. Patch tests of aqueous gold compound induced a strong skin reaction. A histologic study of the patch test reaction sites revealed a picture of ordinary allergic contact dermatitis showing that T cells, including both helper and suppressor T cells, invaded the spongiotic epidermis and the papillary dermis. Eosinophils and a few Langerhans cells were also present in the dermal infiltrates. These findings suggest that pierced-type gold earrings induced a long-term dermal response that resulted in producing benign lymphoplasia in the sensitized individuals.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume16
Issue number1 PART I
DOIs
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

Gold
Patch Tests
Dermis
T-Lymphocytes
Skin
Gold Compounds
Pseudolymphoma
Allergic Contact Dermatitis
Langerhans Cells
Differentiation Antigens
Subcutaneous Tissue
Helper-Inducer T-Lymphocytes
Eosinophils
Epidermis
Lymphocytes
Biopsy

ASJC Scopus subject areas

  • Dermatology

Cite this

Benign lymphoplasia of the earlobes induced by gold earrings : Immunohistologic study on the cellular infiltrates. / Iwatsuki, Keiji; Yamada, Mizuho; Takigawa, Masahiro; Inoue, Kunio; Matsumoto, Kichiro.

In: Journal of the American Academy of Dermatology, Vol. 16, No. 1 PART I, 1987, p. 83-88.

Research output: Contribution to journalArticle

Iwatsuki, Keiji ; Yamada, Mizuho ; Takigawa, Masahiro ; Inoue, Kunio ; Matsumoto, Kichiro. / Benign lymphoplasia of the earlobes induced by gold earrings : Immunohistologic study on the cellular infiltrates. In: Journal of the American Academy of Dermatology. 1987 ; Vol. 16, No. 1 PART I. pp. 83-88.
@article{55cd8ad31a6e4c1cbc6801b5357fa0ab,
title = "Benign lymphoplasia of the earlobes induced by gold earrings: Immunohistologic study on the cellular infiltrates",
abstract = "We report three patients with peculiar nodules of the earlobes that developed a few months after the wearing of pierced-type gold earrings. Biopsy specimens showed dense infiltration of lymphoid cells in the dermis and subcutaneous tissue associated with the formation of lymphoid follicles. The clinical and histologic pictures were similar to those of lymphocytoma cutis. Immunohistologically, the nodular lesions were characterized by the proliferation of T cells, mainly suppressor/cytotoxic T cells, and the presence of histiocytic cells displaying Leu-3a antigens on the surface. Patch tests of aqueous gold compound induced a strong skin reaction. A histologic study of the patch test reaction sites revealed a picture of ordinary allergic contact dermatitis showing that T cells, including both helper and suppressor T cells, invaded the spongiotic epidermis and the papillary dermis. Eosinophils and a few Langerhans cells were also present in the dermal infiltrates. These findings suggest that pierced-type gold earrings induced a long-term dermal response that resulted in producing benign lymphoplasia in the sensitized individuals.",
author = "Keiji Iwatsuki and Mizuho Yamada and Masahiro Takigawa and Kunio Inoue and Kichiro Matsumoto",
year = "1987",
doi = "10.1016/S0190-9622(87)70007-3",
language = "English",
volume = "16",
pages = "83--88",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "1 PART I",

}

TY - JOUR

T1 - Benign lymphoplasia of the earlobes induced by gold earrings

T2 - Immunohistologic study on the cellular infiltrates

AU - Iwatsuki, Keiji

AU - Yamada, Mizuho

AU - Takigawa, Masahiro

AU - Inoue, Kunio

AU - Matsumoto, Kichiro

PY - 1987

Y1 - 1987

N2 - We report three patients with peculiar nodules of the earlobes that developed a few months after the wearing of pierced-type gold earrings. Biopsy specimens showed dense infiltration of lymphoid cells in the dermis and subcutaneous tissue associated with the formation of lymphoid follicles. The clinical and histologic pictures were similar to those of lymphocytoma cutis. Immunohistologically, the nodular lesions were characterized by the proliferation of T cells, mainly suppressor/cytotoxic T cells, and the presence of histiocytic cells displaying Leu-3a antigens on the surface. Patch tests of aqueous gold compound induced a strong skin reaction. A histologic study of the patch test reaction sites revealed a picture of ordinary allergic contact dermatitis showing that T cells, including both helper and suppressor T cells, invaded the spongiotic epidermis and the papillary dermis. Eosinophils and a few Langerhans cells were also present in the dermal infiltrates. These findings suggest that pierced-type gold earrings induced a long-term dermal response that resulted in producing benign lymphoplasia in the sensitized individuals.

AB - We report three patients with peculiar nodules of the earlobes that developed a few months after the wearing of pierced-type gold earrings. Biopsy specimens showed dense infiltration of lymphoid cells in the dermis and subcutaneous tissue associated with the formation of lymphoid follicles. The clinical and histologic pictures were similar to those of lymphocytoma cutis. Immunohistologically, the nodular lesions were characterized by the proliferation of T cells, mainly suppressor/cytotoxic T cells, and the presence of histiocytic cells displaying Leu-3a antigens on the surface. Patch tests of aqueous gold compound induced a strong skin reaction. A histologic study of the patch test reaction sites revealed a picture of ordinary allergic contact dermatitis showing that T cells, including both helper and suppressor T cells, invaded the spongiotic epidermis and the papillary dermis. Eosinophils and a few Langerhans cells were also present in the dermal infiltrates. These findings suggest that pierced-type gold earrings induced a long-term dermal response that resulted in producing benign lymphoplasia in the sensitized individuals.

UR - http://www.scopus.com/inward/record.url?scp=0023151894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023151894&partnerID=8YFLogxK

U2 - 10.1016/S0190-9622(87)70007-3

DO - 10.1016/S0190-9622(87)70007-3

M3 - Article

C2 - 3100585

AN - SCOPUS:0023151894

VL - 16

SP - 83

EP - 88

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 1 PART I

ER -