Benefits and adverse events among elderly patients receiving concurrent chemoradiotherapy for locally advanced non-small cell lung cancer: Analysis of the Okayama lung cancer study group trial 0007

Nagio Takigawa, Katsuyuki Kiura, Yoshihiko Segawa, Katsuyuki Hotta, Akihiko Tamaoki, Yoshiyuki Tokuda, Takuya Nagata, Kazuhiko Watanabe, Kenichi Gemba, Tomonori Moritaka, Naokatsu Horita, Hiromasa Takeda, Niro Okimoto, Mitsuhiro Takemoto, Keitaro Matsuo, Tetsu Shinkai, Masahiro Tabata, Hiroshi Ueoka, Susumu Kanazawa, Mitsune Tanimoto

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Abstract

Introduction: Thoracic radiotherapy (RT) with concurrent chemotherapy may be offered to selected elderly patients with locally advanced non-small cell lung cancer. The Okayama Lung Cancer Study Group (OLCSG) 0007 trial with patients up to 75 years showed that with concurrent RT, docetaxel and cisplatin (DP) chemotherapy was an alternative to mitomycin C, vindesine, and cisplatin (MVP) chemotherapy. Methods: Of the 99 patients in the DP arm, 73 were younger than 70 years and 26 were 70 years or older. Of the 101 patients in the MVP arm, 75 were younger than 70 years and 26 were 70 years or older. Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method and were compared using an early period weighted log-rank test. Toxicities and treatment intensities were compared by χ and t tests, respectively. Results: OS and PFS tended to be longer in the DP arm versus MVP arm: median OS (months), 27.5 versus 22.9 (p = 0.109) and 25.6 versus 23.4 (p = 0.064) in the ≥70-year and

Original languageEnglish
Pages (from-to)1087-1091
Number of pages5
JournalJournal of Thoracic Oncology
Volume6
Issue number6
DOIs
Publication statusPublished - Jun 2011

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Keywords

  • Chemotherapy
  • Elderly
  • Non-small cell lung cancer
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Takigawa, N., Kiura, K., Segawa, Y., Hotta, K., Tamaoki, A., Tokuda, Y., Nagata, T., Watanabe, K., Gemba, K., Moritaka, T., Horita, N., Takeda, H., Okimoto, N., Takemoto, M., Matsuo, K., Shinkai, T., Tabata, M., Ueoka, H., Kanazawa, S., & Tanimoto, M. (2011). Benefits and adverse events among elderly patients receiving concurrent chemoradiotherapy for locally advanced non-small cell lung cancer: Analysis of the Okayama lung cancer study group trial 0007. Journal of Thoracic Oncology, 6(6), 1087-1091. https://doi.org/10.1097/JTO.0b013e318213f86a