Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model

Fusako Takayama, Kazuo Nakamoto, Hiromu Kawasaki, Mitsumasa Mankura, Toru Egashira, Keiji Ueki, Azusa Hasegawa, Shigeru Okada, Akitane Mori

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17 Citations (Scopus)


Vitis coignetiae Pulliat (Yamabudo) is used as a health juice and wine based on the abundant polyphenols and anthocyanins in its fruit. However, it is not known whether the leaves of this plant confer similar benefits. This study investigated the hepatoprotective effects of aqueous extracts from Vitis coignetiae Pulliat leaves (VCPL) in an animal model of nonalcoholic steatohepatitis (NASH). Rats were fed a choline-deficient high-fat diet for four weeks to generate fatty livers. NASH was induced by oxidative stress loading. Ten weeks later, blood and liver samples were collected from anesthe-tized animals and assessed biochemically, histologically, and histochemically to determine the extent of oxidative stress injury and the overall effects of VCPL. Six-week VCPL extract supplementation reduced serum levels of liver enzymes, decreased CYP2E1 induction, increased plasma antioxidant activities and delayed the progression of liver fibrosis. The findings suggested that VCPL has strong radical-scavenging activity and may be beneficial in preventing NASH progression.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalActa medica Okayama
Issue number2
Publication statusPublished - May 2009


  • Antioxidant
  • Hepatoprotection
  • Nonalcoholic steatohepatitis
  • Yamabudo

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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