Behavioral and affective features of amyotrophic lateral sclerosis patients

Yasuyuki Ohta, Kota Sato, Mami Takemoto, Yoshiaki Takahashi, Ryuta Morihara, Yumiko Nakano, Keiichiro Tsunoda, Emi Nomura, Nozomi Hishikawa, Toru Yamashita, Koji Abe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Evaluating the cognitive and behavioral features in amyotrophic lateral sclerosis (ALS) patients is important for therapy and care. Fifty-seven ALS, 5 ALS with the behavioral variant of frontotemporal dementia (FTD) (ALS-FTD), 12 FTD patients, and 35 control subjects were evaluated by 10 different tests for cognitive and behavioral (mini-mental state examination (MMSE), Hasegawa dementia rating scale – revised (HDS-R), frontal assessment battery (FAB), Montreal cognitive assessment (MoCA), ALS-frontotemporal dementia-Questionnaire (ALS-FTD-Q), and anosognosia scale), affective (depression, apathy, and behavioral and psychological symptoms of dementia (BPSD)), and activities of daily living (ADL) assessments. The motor functions of ALS patients were evaluated by ALS functional rating scale – revised (ALSFRS-R) and modified Norris scale. ALS-FTD-Q scores showed intermediate behavioral disturbances of ALS patients between ALS-FTD and FTD patients and control subjects, but FAB, MoCA, and anosognosia scales did not. Both FAB and MoCA scores were significantly correlated with MMSE and HDS-R in ALS patients, but ALS-FTD-Q was not. ALS-FTD-Q score was significantly correlated with ALSFRS-R, apathy, BPSD, and ADL scores in ALS patients. Thus, in ALS patients, both FAB and MoCA tests were useful to assess frontal cognitive impairments, while ALS-FTD-Q was useful to detect mild behavioral and affective disturbances.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalJournal of the Neurological Sciences
Volume381
DOIs
Publication statusPublished - Oct 15 2017

Fingerprint

Amyotrophic Lateral Sclerosis
Frontotemporal Dementia
Dementia
Agnosia
Apathy
Behavioral Symptoms
Activities of Daily Living
Psychology
Frontotemporal Dementia With Motor Neuron Disease
Depression

Keywords

  • ALS
  • ALS-FTD-Q
  • Anosognosia
  • FAB
  • FTD
  • MoCA

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Behavioral and affective features of amyotrophic lateral sclerosis patients. / Ohta, Yasuyuki; Sato, Kota; Takemoto, Mami; Takahashi, Yoshiaki; Morihara, Ryuta; Nakano, Yumiko; Tsunoda, Keiichiro; Nomura, Emi; Hishikawa, Nozomi; Yamashita, Toru; Abe, Koji.

In: Journal of the Neurological Sciences, Vol. 381, 15.10.2017, p. 119-125.

Research output: Contribution to journalArticle

Ohta, Yasuyuki ; Sato, Kota ; Takemoto, Mami ; Takahashi, Yoshiaki ; Morihara, Ryuta ; Nakano, Yumiko ; Tsunoda, Keiichiro ; Nomura, Emi ; Hishikawa, Nozomi ; Yamashita, Toru ; Abe, Koji. / Behavioral and affective features of amyotrophic lateral sclerosis patients. In: Journal of the Neurological Sciences. 2017 ; Vol. 381. pp. 119-125.
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