Abstract
Autologous tissue graft is one of the treatment options for a large rotator cuff defect. To develop appropriate strategies for enhanced solid graft integration at the bone-tendon interface and tendon-tendon interface, clarifying the fate of the graft and host cells that contribute to repair and remodeling is necessary. We have developed a new grafting model using green fluorescent protein-transgenic rats and wild-type rats to simulate autologous transplantation for examining the behavior of the host and graft cells in the remodeling process after tendon grafting. We found that the host cells commenced proliferation in the graft at 1 day after grafting. The host cells infiltrated into the graft from the subacromial synovium, proximal tendon, and bone-tendon insertion. The number of graft-derived cells decreased with time. Our result clearly demonstrated that host cells, rather than graft cells, were essential for rotator cuff remodeling after tendon grafting for rotator cuff defect.
| Original language | English |
|---|---|
| Journal | Journal of Shoulder and Elbow Surgery |
| Volume | 17 |
| Issue number | 1 SUPPL. |
| DOIs | |
| Publication status | Published - Jan 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Surgery
Cite this
Behavior of host and graft cells in the early remodeling process of rotator cuff defects in a transgenic animal model. / Iwata, Yoshio; Morihara, Toru; Tachiiri, Hisakazu; Kajikawa, Yoshiteru; Yoshida, Atsuhiko; Arai, Yuji; Tokunaga, Daisaku; Sakamoto, Hirotaka; Matsuda, Ken ichi; Kurokawa, Masao; Kawata, Mitsuhiro; Kubo, Toshikazu.
In: Journal of Shoulder and Elbow Surgery, Vol. 17, No. 1 SUPPL., 01.2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Behavior of host and graft cells in the early remodeling process of rotator cuff defects in a transgenic animal model
AU - Iwata, Yoshio
AU - Morihara, Toru
AU - Tachiiri, Hisakazu
AU - Kajikawa, Yoshiteru
AU - Yoshida, Atsuhiko
AU - Arai, Yuji
AU - Tokunaga, Daisaku
AU - Sakamoto, Hirotaka
AU - Matsuda, Ken ichi
AU - Kurokawa, Masao
AU - Kawata, Mitsuhiro
AU - Kubo, Toshikazu
PY - 2008/1
Y1 - 2008/1
N2 - Autologous tissue graft is one of the treatment options for a large rotator cuff defect. To develop appropriate strategies for enhanced solid graft integration at the bone-tendon interface and tendon-tendon interface, clarifying the fate of the graft and host cells that contribute to repair and remodeling is necessary. We have developed a new grafting model using green fluorescent protein-transgenic rats and wild-type rats to simulate autologous transplantation for examining the behavior of the host and graft cells in the remodeling process after tendon grafting. We found that the host cells commenced proliferation in the graft at 1 day after grafting. The host cells infiltrated into the graft from the subacromial synovium, proximal tendon, and bone-tendon insertion. The number of graft-derived cells decreased with time. Our result clearly demonstrated that host cells, rather than graft cells, were essential for rotator cuff remodeling after tendon grafting for rotator cuff defect.
AB - Autologous tissue graft is one of the treatment options for a large rotator cuff defect. To develop appropriate strategies for enhanced solid graft integration at the bone-tendon interface and tendon-tendon interface, clarifying the fate of the graft and host cells that contribute to repair and remodeling is necessary. We have developed a new grafting model using green fluorescent protein-transgenic rats and wild-type rats to simulate autologous transplantation for examining the behavior of the host and graft cells in the remodeling process after tendon grafting. We found that the host cells commenced proliferation in the graft at 1 day after grafting. The host cells infiltrated into the graft from the subacromial synovium, proximal tendon, and bone-tendon insertion. The number of graft-derived cells decreased with time. Our result clearly demonstrated that host cells, rather than graft cells, were essential for rotator cuff remodeling after tendon grafting for rotator cuff defect.
UR - http://www.scopus.com/inward/record.url?scp=38049177802&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38049177802&partnerID=8YFLogxK
U2 - 10.1016/j.jse.2007.07.008
DO - 10.1016/j.jse.2007.07.008
M3 - Article
C2 - 18162414
AN - SCOPUS:38049177802
VL - 17
JO - Journal of Shoulder and Elbow Surgery
JF - Journal of Shoulder and Elbow Surgery
SN - 1058-2746
IS - 1 SUPPL.
ER -