Behçet's disease (Adamantiades-Behçet's disease)

Fumio Kaneko, Ari Togashi, Sanae Saito, Hideo Sakuma, Noritaka Oyama, Koichiro Nakamura, Kenji Yokota, Keiji Oguma

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Adamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements. The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oral streptococci mediated by IL-12 cytokine family. HLA-B51 is associated in more than 60 of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues. Bes-1 gene encoded partial S. sanguinis genome which is highly homologous with retinal protein, and 65kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60% in the pathogenesis of ABD. Although Hsp-65/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients. On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage.

Original languageEnglish
Article number681956
JournalClinical and Developmental Immunology
Volume2011
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Kaneko, F., Togashi, A., Saito, S., Sakuma, H., Oyama, N., Nakamura, K., Yokota, K., & Oguma, K. (2011). Behçet's disease (Adamantiades-Behçet's disease). Clinical and Developmental Immunology, 2011, [681956]. https://doi.org/10.1155/2011/681956