Bax protein-like immunoreactivity in primary sensory and hypothalamic neurons of adult rats

Tomosada Sugimoto, Chun Xiao, Yi Fen He, Hiroyuki Ichikawa

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Bax protein-like immunoreactivity (Bax-ir) was examined in the perfusion-fixed, cryosectioned rat nervous system. In the central nervous system, hypothalamic neurons were the only neurons that exhibited Bax-ir in the cell body. Their axons traveled toward the median eminence, suggesting that the Bax-like immunoreactive (Bax-ir) hypothalamic neurons included neurosecretory ones. Bax-ir axons were observed in the solitary tract nucleus, and spinal and medullary dorsal hems. They appear to have been derived from Bax-ir primary sensory neurons in the viscerosensory nodose ganglion and somatosensory dorsal root and trigeminal ganglia. In the somatosensory ganglia, smaller cells exhibited stronger Bax-ir. Accordingly, the ir axons in the dorsal horn were most concentrated in lamina II.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - Aug 30 1996



  • Bax
  • Dorsal horn
  • Hypothalamus
  • Parabrachial nucleus
  • Primary sensory neurons
  • Solitary tract nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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