Basic studies on combined used of cisplatin and Japanese Kampo medicines, Sho-saiko-to, Hochu-ekki-to and Ninzin-yoei-to

T. Egashira, Fusako Takayama, Y. Itou, N. Itonaga, A. Kodomari, Y. Tokikawa, Y. Matsuo, Y. Matsushima, M. Moriwaki, E. Watanabe, Y. Yamanaka

Research output: Contribution to journalArticle

Abstract

Effects of oral administration of Japanese Kampo medicines, Sho-saiko- to, Hochu-ekki-to and Ninzin-yoei-to on the toxic side effects of cisplatin was examined by using ddY male mice. After administration of Japanese Kampo medicines for 1 week or 1 month, we injected cisplatin 0.6 mg/kg i.p. for 7days. Significant depression of the body weight, increases of GOT, GPT and LDH in serum, and decrease of platelets were observed with only cisplatin administration. Daily consecutive oral administration of Hochu-ekki-to and Ninzin-yoei-to at a dosage of 1g/kg/day showed a tendency to improve the depression of body weight by cisplatin. While, Sho-saiko-to and Ninzin-yoei- to showed a tendency to suppress the elevation of GOT and LDH levels, respectively. These results suggest that pre-and post-administration of Japanese Kampo medicines are the most useful supporting drugs for prevention of the toxic side effects of cisplatin during cancer chemotherapy.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalJapanese Pharmacology and Therapeutics
Volume25
Issue number10
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Kampo Medicine
Cisplatin
Poisons
Oral Administration
Body Weight
Blood Platelets
bu-zhong-yi-qi-tang
shosaiko-to
Drug Therapy
Serum
Pharmaceutical Preparations
Neoplasms

Keywords

  • Cisplatin
  • Hochu-ekki-to
  • Ninzin-yoei-to
  • Sho-saiko-to

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Basic studies on combined used of cisplatin and Japanese Kampo medicines, Sho-saiko-to, Hochu-ekki-to and Ninzin-yoei-to. / Egashira, T.; Takayama, Fusako; Itou, Y.; Itonaga, N.; Kodomari, A.; Tokikawa, Y.; Matsuo, Y.; Matsushima, Y.; Moriwaki, M.; Watanabe, E.; Yamanaka, Y.

In: Japanese Pharmacology and Therapeutics, Vol. 25, No. 10, 1997, p. 71-77.

Research output: Contribution to journalArticle

Egashira, T, Takayama, F, Itou, Y, Itonaga, N, Kodomari, A, Tokikawa, Y, Matsuo, Y, Matsushima, Y, Moriwaki, M, Watanabe, E & Yamanaka, Y 1997, 'Basic studies on combined used of cisplatin and Japanese Kampo medicines, Sho-saiko-to, Hochu-ekki-to and Ninzin-yoei-to', Japanese Pharmacology and Therapeutics, vol. 25, no. 10, pp. 71-77.
Egashira, T. ; Takayama, Fusako ; Itou, Y. ; Itonaga, N. ; Kodomari, A. ; Tokikawa, Y. ; Matsuo, Y. ; Matsushima, Y. ; Moriwaki, M. ; Watanabe, E. ; Yamanaka, Y. / Basic studies on combined used of cisplatin and Japanese Kampo medicines, Sho-saiko-to, Hochu-ekki-to and Ninzin-yoei-to. In: Japanese Pharmacology and Therapeutics. 1997 ; Vol. 25, No. 10. pp. 71-77.
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