Basic research and clinical investigations of the neural basis of orofacial pain

Yoshizo Matsuka, Koichi Iwata, Ryuji Terayama, Yoshiki Imamura, Kotaro Maruhama, Masamichi Shinoda, Yoshiyuki Tsuboi, Masahiro Kondo, Kuniya Honda, Ayano Katagiri, Tomosada Sugimoto

Research output: Contribution to journalArticle

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Abstract

Background Trigeminal nerve injury or orofacial inflammation causes severe pain in the orofacial regions innervated by uninjured nerves or uninflamed tissues as well as injured or inflamed tissues. Pathological orofacial pain associated with trigeminal nerve injury or inflammation is difficult to diagnose and treat. Highlight To develop appropriate treatments for patients with orofacial pathological pain, various animal models of trigeminal nerve injury or orofacial inflammation have been developed. Further, the possible mechanisms involving the trigeminal ganglion (TG), trigeminal spinal subnucleus caudalis (Vc), and upper cervical spinal cord (C1-C2) have been studied. Conclusion (1) Neurotransmitters released from the somata of TG neurons are involved in peripheral sensitization. (2) Neurotransmitter release from TG neurons is decreased by botulinum toxin-type A administration, suggesting that this toxin suppressed neurotransmitter release and alleviated the neuropathic pain-related behavior. (3) Altered states of glial cells and nociceptive neurons, in the Vc and C1-C2 are involved in pathological orofacial pain associated with trigeminal nerve injury or orofacial inflammation. (4) The trigeminal sensory nuclear complex, especially the trigeminal spinal subnucleus oralis, is involved in normal and pathological orofacial pain conditions after peripheral nerve injury. (5) Neuroimaging analyses have suggested functional changes in the central and peripheral nervous systems in neuropathic pain conditions.

Original languageEnglish
Pages (from-to)27-36
Number of pages10
JournalJournal of Oral Biosciences
Volume57
Issue number1
DOIs
Publication statusPublished - Feb 1 2015

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Trigeminal Nerve Injuries
Facial Pain
Neurons
Neurotransmitter Agents
Trigeminal Ganglion
Inflammation
Research
Tissue
Neuroimaging
Neuralgia
Type A Botulinum Toxins
Neurology
Carisoprodol
Trigeminal Nuclei
Animals
Peripheral Nerve Injuries
Nociceptors
Peripheral Nervous System
Neuroglia
Central Nervous System

Keywords

  • Glial cell
  • Nerve injury
  • Neuroimaging
  • Orofacial
  • pathological pain
  • Trigeminal sensory nuclear complex

ASJC Scopus subject areas

  • Dentistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine (miscellaneous)

Cite this

Matsuka, Y., Iwata, K., Terayama, R., Imamura, Y., Maruhama, K., Shinoda, M., ... Sugimoto, T. (2015). Basic research and clinical investigations of the neural basis of orofacial pain. Journal of Oral Biosciences, 57(1), 27-36. https://doi.org/10.1016/j.job.2014.09.001

Basic research and clinical investigations of the neural basis of orofacial pain. / Matsuka, Yoshizo; Iwata, Koichi; Terayama, Ryuji; Imamura, Yoshiki; Maruhama, Kotaro; Shinoda, Masamichi; Tsuboi, Yoshiyuki; Kondo, Masahiro; Honda, Kuniya; Katagiri, Ayano; Sugimoto, Tomosada.

In: Journal of Oral Biosciences, Vol. 57, No. 1, 01.02.2015, p. 27-36.

Research output: Contribution to journalArticle

Matsuka, Y, Iwata, K, Terayama, R, Imamura, Y, Maruhama, K, Shinoda, M, Tsuboi, Y, Kondo, M, Honda, K, Katagiri, A & Sugimoto, T 2015, 'Basic research and clinical investigations of the neural basis of orofacial pain', Journal of Oral Biosciences, vol. 57, no. 1, pp. 27-36. https://doi.org/10.1016/j.job.2014.09.001
Matsuka Y, Iwata K, Terayama R, Imamura Y, Maruhama K, Shinoda M et al. Basic research and clinical investigations of the neural basis of orofacial pain. Journal of Oral Biosciences. 2015 Feb 1;57(1):27-36. https://doi.org/10.1016/j.job.2014.09.001
Matsuka, Yoshizo ; Iwata, Koichi ; Terayama, Ryuji ; Imamura, Yoshiki ; Maruhama, Kotaro ; Shinoda, Masamichi ; Tsuboi, Yoshiyuki ; Kondo, Masahiro ; Honda, Kuniya ; Katagiri, Ayano ; Sugimoto, Tomosada. / Basic research and clinical investigations of the neural basis of orofacial pain. In: Journal of Oral Biosciences. 2015 ; Vol. 57, No. 1. pp. 27-36.
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