TY - JOUR
T1 - Basic and clinical studies on FK037 in respiratory infection
AU - Fukuhara, Hiroshi
AU - Inadome, Jun
AU - Kakazu, Tomokazu
AU - Nakamura, Hiroaki
AU - Kaneshima, Hiroshi
AU - Saito, Atsushi
AU - Kusano, Nobuchika
AU - Nakasone, Isamu
AU - Furugen, Yoshiko
AU - Taira, Shinko
AU - Hokama, Seitetsu
AU - Tateyama, Masao
AU - Irabu, Yuei
AU - Ueji, Hiroyuki
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1994
Y1 - 1994
N2 - We performed basic and clinical studies on FK037, a new parenteral cephalosporin antibiotic, and the following results were obtained. 1) Antimicrobial activity: The minimum inhibitory concentrations (MIC) of FK037 against a total of 302 clinically isolated strains of 13 species were measured and compared with those of five cephalosporins (ceftazidime, flomoxef, ceftizoxime, cefpirome, cefepime) and one carbapenem (imipenem) using the MIC 2000 System (Dynatech Laboratories). FK037 provided a stronger bactericidal activity than ceftazidime, ceftizoxime and cefepime, and equaled to or was stronger than flomoxef and cefpirome in bactericidal activity against grampositive bacteria, and had stronger bactericidal activity than imipenem, and was equal to or stronger than five cephalosporin antibiotics in bactericidal activity against gram-negative bacteria. FK037 had wide bactericidal activity against these clinical isolated strains except methicillin-resistant Staphylococcus aureus. 2) Clinical study results: FK037 was administered to 4 patients with pneumonia in daily doses of 1.0g to 4.0g for 7~15 days by drip infusion. Clinical response was excellent in one, good in one and fair in one except unknown in one patient. No objective or subjective side effects related to the antibiotic were noted. Abnormal laboratory changes were observed in 2 cases, but were transient.
AB - We performed basic and clinical studies on FK037, a new parenteral cephalosporin antibiotic, and the following results were obtained. 1) Antimicrobial activity: The minimum inhibitory concentrations (MIC) of FK037 against a total of 302 clinically isolated strains of 13 species were measured and compared with those of five cephalosporins (ceftazidime, flomoxef, ceftizoxime, cefpirome, cefepime) and one carbapenem (imipenem) using the MIC 2000 System (Dynatech Laboratories). FK037 provided a stronger bactericidal activity than ceftazidime, ceftizoxime and cefepime, and equaled to or was stronger than flomoxef and cefpirome in bactericidal activity against grampositive bacteria, and had stronger bactericidal activity than imipenem, and was equal to or stronger than five cephalosporin antibiotics in bactericidal activity against gram-negative bacteria. FK037 had wide bactericidal activity against these clinical isolated strains except methicillin-resistant Staphylococcus aureus. 2) Clinical study results: FK037 was administered to 4 patients with pneumonia in daily doses of 1.0g to 4.0g for 7~15 days by drip infusion. Clinical response was excellent in one, good in one and fair in one except unknown in one patient. No objective or subjective side effects related to the antibiotic were noted. Abnormal laboratory changes were observed in 2 cases, but were transient.
KW - FK037
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U2 - 10.11250/chemotherapy1953.42.Supplement3_227
DO - 10.11250/chemotherapy1953.42.Supplement3_227
M3 - Article
AN - SCOPUS:0028127043
VL - 42
SP - 227
EP - 233
JO - Chemotherapy
JF - Chemotherapy
SN - 0009-3165
ER -