Basic and clinical studies on FK037 in complicated urinary tract infections

Toyohiko Watanabe, Tadasu Takenaka, Toshihide Hayashi, Koushi Sakuramoto, Kazuhiro Hata, Noriaki Ono, Hiromi Kumon, Hiroyuki Ohmori, Yasuhiro Katayama, Yoshitaka Yamashita, Teruaki Akaeda

Research output: Contribution to journalArticle

Abstract

We studied the antibacterial activity and efficacy of FK037, a new injectable cephem antibiotic, in the urological field. 1) Antibacterial activity: The MICs of FK037 were measured against 211 clinically isolated strains of 14 species from urinary tract infections and compared with those of ceftazidime (CAZ), cefoperazone (CPZ) and imipenem (IPM). In general, the antibacterial activities of FK037 were superior to those of CAZ and CPZ, but inferior to those of IPM. 2) Clinical efficacy: According to the criteria of Japanese UTI Committee, the overall clinical efficacy rate was 75.0%(9/12) for chronic complicated UTI. Bacteriologically, 18 of 20 strains (90.0%) isolated were eradicated. 3) Side effect: A mild and transient rash was observed in 1 patient. In 1 patient, eosinophilia was noted, but was not problematic clinically. Based on the above findings, FK037 might be useful in the treatment of urinary tract infection.

Original languageEnglish
Pages (from-to)260-268
Number of pages9
JournalCHEMOTHERAPY
Volume42
DOIs
Publication statusPublished - Jan 1 1994

Keywords

  • FK037

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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    Watanabe, T., Takenaka, T., Hayashi, T., Sakuramoto, K., Hata, K., Ono, N., Kumon, H., Ohmori, H., Katayama, Y., Yamashita, Y., & Akaeda, T. (1994). Basic and clinical studies on FK037 in complicated urinary tract infections. CHEMOTHERAPY, 42, 260-268. https://doi.org/10.11250/chemotherapy1953.42.Supplement3_260