Basic and clinical studies on BMY-28100 in urology

Yoshitsugu Nasu, Daisuke Yamada, Masaya Tsugawa, Mikio Kishi, Hiromi Kumon, Hiroyuki Ohmori, Katsuichi Nanba, Nobuyuki Akazawa, Akihiro Mizuno

Research output: Contribution to journalArticle

Abstract

We performed basic and clinical studies on BMY-28100, a new orally active antimicrobial agent, in urology. 1) BMY-28100 had a broad spectrum, showing strong antibacterial activity against Gram-positive bacteria, includingStaphylococcus aureus, Staphylococcus epidermidis and Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniaeand Proteus mirabilis 2) Two patients with acute uncomplicated cystitis showed excellent or good response to BMY-28100 treatment. Six of 14 patients with complicated urinary tract infection showed excellent or moderateresponse. 3) No side effects were observed. Abnormal laboratory findings were noted in 5 episodes in 3 patients, but were mild and transient.

Original languageEnglish
Pages (from-to)606-618
Number of pages13
JournalCHEMOTHERAPY
Volume37
DOIs
Publication statusPublished - Jan 1 1989

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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  • Cite this

    Nasu, Y., Yamada, D., Tsugawa, M., Kishi, M., Kumon, H., Ohmori, H., Nanba, K., Akazawa, N., & Mizuno, A. (1989). Basic and clinical studies on BMY-28100 in urology. CHEMOTHERAPY, 37, 606-618. https://doi.org/10.11250/chemotherapy1953.37.Supplement3_606