Basic and clinical studies on biapenem in genito-urinary infections

Toyohiko Watanabe, Tadasu Takenaka, Toshihide Hayashi, Kazuhiro Hata, Noriaki Ono, Hiromi Kumon, Hiroyuki Ohmori, Keigo Kinugawa, Hiroyoshi Tanaka, Mototaka Takada, Katsuichi Nanba, Katsuji Takeda, Toshihiko Asahi, Satoshi Uno, Taiichiro Jousen

Research output: Contribution to journalArticle

Abstract

We studied the antibacterial activity and clinical efficacy of biapenem (BIPM), a new carbapenem antibiotic, in the genito-urinary, infections. 1) Antibacterial activity: We measured the MICs of BIPM against clinical isolates (210 strains of 14 species) from urinary tract infections, and compared them with those of imipenem (IPM), ceftazidime (CAZ), latamoxef (LMOX) and cefoperazone (CPZ). In general, antibacterial activities of BIPM were almost equal to those of IPM, but superior to those of other control drugs. 2) Clinical efficacy: According to the criteria of Japanese UTI committee, the overall clinical efficacy rate was 73.9%(17/23) for chronic complicated UTI. Bacteriologically, 30 of 35 strains (85.7%) were eradicated. 3) Side effect: Clinical side effects and abnormal laboratory changes were not observed in any cases.

Original languageEnglish
Pages (from-to)486-496
Number of pages11
JournalCHEMOTHERAPY
Volume42
DOIs
Publication statusPublished - 1994

Keywords

  • Biapenem

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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    Watanabe, T., Takenaka, T., Hayashi, T., Hata, K., Ono, N., Kumon, H., Ohmori, H., Kinugawa, K., Tanaka, H., Takada, M., Nanba, K., Takeda, K., Asahi, T., Uno, S., & Jousen, T. (1994). Basic and clinical studies on biapenem in genito-urinary infections. CHEMOTHERAPY, 42, 486-496. https://doi.org/10.11250/chemotherapy1953.42.Supplement4_486