Basic and clinical studies of pazufloxacin in respiratory infections

M. Gaja, M. Tateyama, J. Inadome, H. Fukuhara, A. Saito, Nobuchika Kusano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We performed a basic evaluation of pazufloxacin (PZFX), a newly developed new quinolone agent, and clinically studied its application in the treatment of respiratory infections, with the following results. 1. Antibacterial activity. The minimum inhibitory concentrations (MICs) of PZFX against 272 strains of 12 species isolated from clinical material were measured and compared with those of other new quinolone agents, ofloxacin (OFLX), tosufloxacin (TFLX) and ciprofloxacin (CPFX). The antimicrobial activity of PZFX for gram-positive coccus was the same as that of OFLX and for gram- negative rod was slightly better than those of TFLX and CPFX. 2. Clinical efficacy. Ten patients with respiratory tract infections were given PZFX for 4 to 15 days. Clinical efficacy was assessed as good in 9 cases and poor in 1 case. No side effects were observed.

Original languageEnglish
Pages (from-to)310-315
Number of pages6
JournalJapanese Journal of Chemotherapy
Volume43
Issue numberSUPPL. 2
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

tosufloxacin
Respiratory Tract Infections
Ofloxacin
Quinolones
Ciprofloxacin
Gram-Positive Cocci
Microbial Sensitivity Tests
pazufloxacin
Clinical Studies
Therapeutics

Keywords

  • PZFX

ASJC Scopus subject areas

  • Pharmacology

Cite this

Gaja, M., Tateyama, M., Inadome, J., Fukuhara, H., Saito, A., & Kusano, N. (1995). Basic and clinical studies of pazufloxacin in respiratory infections. Japanese Journal of Chemotherapy, 43(SUPPL. 2), 310-315.

Basic and clinical studies of pazufloxacin in respiratory infections. / Gaja, M.; Tateyama, M.; Inadome, J.; Fukuhara, H.; Saito, A.; Kusano, Nobuchika.

In: Japanese Journal of Chemotherapy, Vol. 43, No. SUPPL. 2, 1995, p. 310-315.

Research output: Contribution to journalArticle

Gaja, M, Tateyama, M, Inadome, J, Fukuhara, H, Saito, A & Kusano, N 1995, 'Basic and clinical studies of pazufloxacin in respiratory infections', Japanese Journal of Chemotherapy, vol. 43, no. SUPPL. 2, pp. 310-315.
Gaja M, Tateyama M, Inadome J, Fukuhara H, Saito A, Kusano N. Basic and clinical studies of pazufloxacin in respiratory infections. Japanese Journal of Chemotherapy. 1995;43(SUPPL. 2):310-315.
Gaja, M. ; Tateyama, M. ; Inadome, J. ; Fukuhara, H. ; Saito, A. ; Kusano, Nobuchika. / Basic and clinical studies of pazufloxacin in respiratory infections. In: Japanese Journal of Chemotherapy. 1995 ; Vol. 43, No. SUPPL. 2. pp. 310-315.
@article{e2780e6d9c584323a819face4ea13139,
title = "Basic and clinical studies of pazufloxacin in respiratory infections",
abstract = "We performed a basic evaluation of pazufloxacin (PZFX), a newly developed new quinolone agent, and clinically studied its application in the treatment of respiratory infections, with the following results. 1. Antibacterial activity. The minimum inhibitory concentrations (MICs) of PZFX against 272 strains of 12 species isolated from clinical material were measured and compared with those of other new quinolone agents, ofloxacin (OFLX), tosufloxacin (TFLX) and ciprofloxacin (CPFX). The antimicrobial activity of PZFX for gram-positive coccus was the same as that of OFLX and for gram- negative rod was slightly better than those of TFLX and CPFX. 2. Clinical efficacy. Ten patients with respiratory tract infections were given PZFX for 4 to 15 days. Clinical efficacy was assessed as good in 9 cases and poor in 1 case. No side effects were observed.",
keywords = "PZFX",
author = "M. Gaja and M. Tateyama and J. Inadome and H. Fukuhara and A. Saito and Nobuchika Kusano",
year = "1995",
language = "English",
volume = "43",
pages = "310--315",
journal = "Japanese Journal of Chemotherapy",
issn = "1340-7007",
publisher = "Japan Society of Chemotherapy",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Basic and clinical studies of pazufloxacin in respiratory infections

AU - Gaja, M.

AU - Tateyama, M.

AU - Inadome, J.

AU - Fukuhara, H.

AU - Saito, A.

AU - Kusano, Nobuchika

PY - 1995

Y1 - 1995

N2 - We performed a basic evaluation of pazufloxacin (PZFX), a newly developed new quinolone agent, and clinically studied its application in the treatment of respiratory infections, with the following results. 1. Antibacterial activity. The minimum inhibitory concentrations (MICs) of PZFX against 272 strains of 12 species isolated from clinical material were measured and compared with those of other new quinolone agents, ofloxacin (OFLX), tosufloxacin (TFLX) and ciprofloxacin (CPFX). The antimicrobial activity of PZFX for gram-positive coccus was the same as that of OFLX and for gram- negative rod was slightly better than those of TFLX and CPFX. 2. Clinical efficacy. Ten patients with respiratory tract infections were given PZFX for 4 to 15 days. Clinical efficacy was assessed as good in 9 cases and poor in 1 case. No side effects were observed.

AB - We performed a basic evaluation of pazufloxacin (PZFX), a newly developed new quinolone agent, and clinically studied its application in the treatment of respiratory infections, with the following results. 1. Antibacterial activity. The minimum inhibitory concentrations (MICs) of PZFX against 272 strains of 12 species isolated from clinical material were measured and compared with those of other new quinolone agents, ofloxacin (OFLX), tosufloxacin (TFLX) and ciprofloxacin (CPFX). The antimicrobial activity of PZFX for gram-positive coccus was the same as that of OFLX and for gram- negative rod was slightly better than those of TFLX and CPFX. 2. Clinical efficacy. Ten patients with respiratory tract infections were given PZFX for 4 to 15 days. Clinical efficacy was assessed as good in 9 cases and poor in 1 case. No side effects were observed.

KW - PZFX

UR - http://www.scopus.com/inward/record.url?scp=0028791478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028791478&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 310

EP - 315

JO - Japanese Journal of Chemotherapy

JF - Japanese Journal of Chemotherapy

SN - 1340-7007

IS - SUPPL. 2

ER -