Basic and clinical associations between bone and cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

Bone is one of the most common distant organs in which tumor cells tend to metastasize depending on complicated immune system and bone microenvironments. Clinical symptoms such as severe pain and bone fractures associated with bone metastases severely affect patients’ quality of life. According to the pathological types of bone destruction caused by the biological characteristics of different primary cancer cells, bone metastases are classified as osteolytic, osteoblastic and mixed types. Herein, we discuss the molecular mechanisms of bone metastasis and the therapeutic strategy with focus on bone metabolism.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalImmunological Medicine
Volume43
Issue number3
DOIs
Publication statusPublished - Jul 2 2020

Keywords

  • Bone metastases
  • bisphosphonates
  • denosumab

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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