Base transitions and base transversions seen in mutations among various types of the hepatitis C viral genome

Torahiko Tanaka, Nobuyuki Kato, Makoto Hijikata, Kunitada Shimotohno

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We counted base transitions (Ts) and transversions (Tv) in mutations among various types of hepatitis C virus (HCV) sequences. The Ts/TV ratio was useful for distinguishing the (geno)type of the compared HCV sequences, since the ratio was 4.0 or more among sequences of the same type, while it was less than 2.0 among sequences of different types. This observation reflects the evolutionary pathway of HCV in which tv accumulate among distant genomes by mechanisms including multiple base substitutions.

Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalFEBS Letters
Volume315
Issue number2
DOIs
Publication statusPublished - Jan 4 1993

Keywords

  • Base transition
  • Base transversion
  • Genotype
  • Hepatitis C virus
  • Multiple base substitution
  • Mutation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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