Base transitions and base transversions seen in mutations among various types of the hepatitis C viral genome

Torahiko Tanaka; Nobuyuki Kato; Makoto Hijikata; Kunitada Shimotohno

doi:10.1016/0014-5793(93)81163-T

Base transitions and base transversions seen in mutations among various types of the hepatitis C viral genome

Torahiko Tanaka, Nobuyuki Kato, Makoto Hijikata, Kunitada Shimotohno

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We counted base transitions (Ts) and transversions (Tv) in mutations among various types of hepatitis C virus (HCV) sequences. The Ts/TV ratio was useful for distinguishing the (geno)type of the compared HCV sequences, since the ratio was 4.0 or more among sequences of the same type, while it was less than 2.0 among sequences of different types. This observation reflects the evolutionary pathway of HCV in which tv accumulate among distant genomes by mechanisms including multiple base substitutions.

Original language	English
Pages (from-to)	201-203
Number of pages	3
Journal	FEBS Letters
Volume	315
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(93)81163-T
Publication status	Published - Jan 4 1993

Keywords

Base transition
Base transversion
Genotype
Hepatitis C virus
Multiple base substitution
Mutation

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1016/0014-5793(93)81163-T

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abstract = "We counted base transitions (Ts) and transversions (Tv) in mutations among various types of hepatitis C virus (HCV) sequences. The Ts/TV ratio was useful for distinguishing the (geno)type of the compared HCV sequences, since the ratio was 4.0 or more among sequences of the same type, while it was less than 2.0 among sequences of different types. This observation reflects the evolutionary pathway of HCV in which tv accumulate among distant genomes by mechanisms including multiple base substitutions.",

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T1 - Base transitions and base transversions seen in mutations among various types of the hepatitis C viral genome

AU - Tanaka, Torahiko

AU - Kato, Nobuyuki

AU - Hijikata, Makoto

AU - Shimotohno, Kunitada

N1 - Funding Information: AcknowledgementsT: his study was supportedb y grants-in-aidf or CancerR esearcha nd for a Comprehensivelo -Year Strategyo f Cancer Control from the Ministry of Health and Welfareo f Japan.

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N2 - We counted base transitions (Ts) and transversions (Tv) in mutations among various types of hepatitis C virus (HCV) sequences. The Ts/TV ratio was useful for distinguishing the (geno)type of the compared HCV sequences, since the ratio was 4.0 or more among sequences of the same type, while it was less than 2.0 among sequences of different types. This observation reflects the evolutionary pathway of HCV in which tv accumulate among distant genomes by mechanisms including multiple base substitutions.

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KW - Base transition

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KW - Genotype

KW - Hepatitis C virus

KW - Multiple base substitution

KW - Mutation

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Base transitions and base transversions seen in mutations among various types of the hepatitis C viral genome

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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