Base transitions and base transversions seen in mutations among various types of the hepatitis C viral genome

Torahiko Tanaka; Nobuyuki Kato; Makoto Hijikata; Kunitada Shimotohno

doi:10.1016/0014-5793(93)81163-T

Base transitions and base transversions seen in mutations among various types of the hepatitis C viral genome

Torahiko Tanaka, Nobuyuki Kato, Makoto Hijikata, Kunitada Shimotohno

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

We counted base transitions (Ts) and transversions (Tv) in mutations among various types of hepatitis C virus (HCV) sequences. The Ts/TV ratio was useful for distinguishing the (geno)type of the compared HCV sequences, since the ratio was 4.0 or more among sequences of the same type, while it was less than 2.0 among sequences of different types. This observation reflects the evolutionary pathway of HCV in which tv accumulate among distant genomes by mechanisms including multiple base substitutions.

Original language	English
Pages (from-to)	201-203
Number of pages	3
Journal	FEBS Letters
Volume	315
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(93)81163-T
Publication status	Published - Jan 4 1993
Externally published	Yes

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Keywords

Base transition
Base transversion
Genotype
Hepatitis C virus
Multiple base substitution
Mutation

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Tanaka, T., Kato, N., Hijikata, M., & Shimotohno, K. (1993). Base transitions and base transversions seen in mutations among various types of the hepatitis C viral genome. FEBS Letters, 315(2), 201-203. https://doi.org/10.1016/0014-5793(93)81163-T

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10.1016/0014-5793(93)81163-T