TY - JOUR
T1 - Basaloid squamous cell carcinoma of the tongue in a Japanese male patient
T2 - A case report
AU - Shinno, Yasuo
AU - Nagatsuka, Hitoshi
AU - Siar, Chong Huat
AU - Tsujigiwa, Hidetsugu
AU - Tamamura, Ryo
AU - Gunduz, Mehmet
AU - Lee, You Jin
AU - Sasaki, Akira
AU - Nagai, Noriyuki
N1 - Funding Information:
This work was supported by grant-in-aid for scientific research A from Ministry of Education, Science, Sports and Culture of Japan (N.N.#15209060).
PY - 2005/4
Y1 - 2005/4
N2 - Basaloid squamous cell carcinoma (BSCC) is a virulent variant of squamous cell carcinoma. We present a case of BSCC affecting the tongue of a 57-year old Japanese male. Microscopically, BSCC was diagnosed on the basis of presence of basaloid carcinomatous component in intimate contact with smaller areas of conventional squamous cell carcinoma. Immunohistochemistry demonstrated positive staining of tumor epithelium for pan-keratin marker MNF116, CK8, CK17, CK19 and CEA, weak immunoreactivity for CK14, EMA and S-100 protein and negative staining for CK1 and alpha-smooth muscle actin. The principal differential diagnoses considered were adenoid cystic carcinoma, adenosquamous carcinoma and polymorphous low-grade adenocarcinoma.
AB - Basaloid squamous cell carcinoma (BSCC) is a virulent variant of squamous cell carcinoma. We present a case of BSCC affecting the tongue of a 57-year old Japanese male. Microscopically, BSCC was diagnosed on the basis of presence of basaloid carcinomatous component in intimate contact with smaller areas of conventional squamous cell carcinoma. Immunohistochemistry demonstrated positive staining of tumor epithelium for pan-keratin marker MNF116, CK8, CK17, CK19 and CEA, weak immunoreactivity for CK14, EMA and S-100 protein and negative staining for CK1 and alpha-smooth muscle actin. The principal differential diagnoses considered were adenoid cystic carcinoma, adenosquamous carcinoma and polymorphous low-grade adenocarcinoma.
KW - Basaloid squamous cell carcinoma
KW - Immunohistochemistry
KW - Tongue
UR - http://www.scopus.com/inward/record.url?scp=15944398000&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=15944398000&partnerID=8YFLogxK
U2 - 10.1016/j.ooe.2004.12.002
DO - 10.1016/j.ooe.2004.12.002
M3 - Article
AN - SCOPUS:15944398000
SN - 1741-9409
VL - 41
SP - 65
EP - 69
JO - Oral Oncology Extra
JF - Oral Oncology Extra
IS - 4
ER -