Basal protrusion of ulcers induced by Endoscopic Submucosal Dissection (ESD) during treatment with proton pump inhibitors, and the suppressive effects of polaprezinc

Tomoki Inaba, Shigenao Ishikawa, Tatsuya Toyokawa, Hisashi Ishikawa, Koji Miyahara, Masaki Wato, Kozo Kawai, Hiroyuki Okada, Kazuhide Yamamoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background/Aims: When a peptic ulcer is treated with proton pump inhibitors (PPI), protrusion of the ulcer base is sometimes noted during ulcer healing. To clarify the incidence of ulcer base protrusion in ulcers induced by endoscopic submucosal dissection (ESD), and whether the addition of polaprezinc, a cytoprotective agent used for treatment of gastric ulcer, to the PPI regimen helps to suppress it. Methodology: One hundred sixty-three patients on which ESD was performed were randomly allocated to either two groups: one treated with lansoprazole (30mg/day) and the other with lansoprazole (30mg/day) plus polaprezinc (150mg/day) for the treatment of ESD-induced ulcer. The condition of the ESD-induced ulcer was blindly assessed two months after ESD by two physicians. Results: Lansoprazole plus polaprezinc group showed significantly better ulcer healing (p<0.0001) and protrusion of the ulcer base was recognized in only 1.3% (1/77), an incidence significantly lower than that in lansoprazole group (20.7%, 16/77, p=0.0001). Polaprezinc was the only significant factor (p=0.0001) differentiating patients who had ulcer base protrusion (n=17) from those who did not (n=137). Conclusions: Polaprezinc prevents protrusion of the ulcer base during the healing of ESD-induced ulcer with PPI.

Original languageEnglish
Pages (from-to)678-684
Number of pages7
JournalHepato-gastroenterology
Volume57
Issue number99-100
Publication statusPublished - May 2010

Keywords

  • Endoscopic submucosal dissection
  • Gastric ulcer healing
  • Polaprezinc
  • Proton pump inhibitor
  • Protrusion of ulcer base

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Inaba, T., Ishikawa, S., Toyokawa, T., Ishikawa, H., Miyahara, K., Wato, M., Kawai, K., Okada, H., & Yamamoto, K. (2010). Basal protrusion of ulcers induced by Endoscopic Submucosal Dissection (ESD) during treatment with proton pump inhibitors, and the suppressive effects of polaprezinc. Hepato-gastroenterology, 57(99-100), 678-684.