TY - JOUR
T1 - Basal protrusion of ulcers induced by Endoscopic Submucosal Dissection (ESD) during treatment with proton pump inhibitors, and the suppressive effects of polaprezinc
AU - Inaba, Tomoki
AU - Ishikawa, Shigenao
AU - Toyokawa, Tatsuya
AU - Ishikawa, Hisashi
AU - Miyahara, Koji
AU - Wato, Masaki
AU - Kawai, Kozo
AU - Okada, Hiroyuki
AU - Yamamoto, Kazuhide
PY - 2010/5
Y1 - 2010/5
N2 - Background/Aims: When a peptic ulcer is treated with proton pump inhibitors (PPI), protrusion of the ulcer base is sometimes noted during ulcer healing. To clarify the incidence of ulcer base protrusion in ulcers induced by endoscopic submucosal dissection (ESD), and whether the addition of polaprezinc, a cytoprotective agent used for treatment of gastric ulcer, to the PPI regimen helps to suppress it. Methodology: One hundred sixty-three patients on which ESD was performed were randomly allocated to either two groups: one treated with lansoprazole (30mg/day) and the other with lansoprazole (30mg/day) plus polaprezinc (150mg/day) for the treatment of ESD-induced ulcer. The condition of the ESD-induced ulcer was blindly assessed two months after ESD by two physicians. Results: Lansoprazole plus polaprezinc group showed significantly better ulcer healing (p<0.0001) and protrusion of the ulcer base was recognized in only 1.3% (1/77), an incidence significantly lower than that in lansoprazole group (20.7%, 16/77, p=0.0001). Polaprezinc was the only significant factor (p=0.0001) differentiating patients who had ulcer base protrusion (n=17) from those who did not (n=137). Conclusions: Polaprezinc prevents protrusion of the ulcer base during the healing of ESD-induced ulcer with PPI.
AB - Background/Aims: When a peptic ulcer is treated with proton pump inhibitors (PPI), protrusion of the ulcer base is sometimes noted during ulcer healing. To clarify the incidence of ulcer base protrusion in ulcers induced by endoscopic submucosal dissection (ESD), and whether the addition of polaprezinc, a cytoprotective agent used for treatment of gastric ulcer, to the PPI regimen helps to suppress it. Methodology: One hundred sixty-three patients on which ESD was performed were randomly allocated to either two groups: one treated with lansoprazole (30mg/day) and the other with lansoprazole (30mg/day) plus polaprezinc (150mg/day) for the treatment of ESD-induced ulcer. The condition of the ESD-induced ulcer was blindly assessed two months after ESD by two physicians. Results: Lansoprazole plus polaprezinc group showed significantly better ulcer healing (p<0.0001) and protrusion of the ulcer base was recognized in only 1.3% (1/77), an incidence significantly lower than that in lansoprazole group (20.7%, 16/77, p=0.0001). Polaprezinc was the only significant factor (p=0.0001) differentiating patients who had ulcer base protrusion (n=17) from those who did not (n=137). Conclusions: Polaprezinc prevents protrusion of the ulcer base during the healing of ESD-induced ulcer with PPI.
KW - Endoscopic submucosal dissection
KW - Gastric ulcer healing
KW - Polaprezinc
KW - Proton pump inhibitor
KW - Protrusion of ulcer base
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M3 - Article
C2 - 20698249
AN - SCOPUS:77955499262
VL - 57
SP - 678
EP - 684
JO - Acta hepato-splenologica
JF - Acta hepato-splenologica
SN - 0172-6390
IS - 99-100
ER -