Bacteremia due to high-level daptomycin-resistant Corynebacterium striatum: A case report with genetic investigation

Hideharu Hagiya, Keigo Kimura, Hideo Okuno, Shigeto Hamaguchi, Daiichi Morii, Hisao Yoshida, Tomomi Mitsui, Isao Nishi, Kazunori Tomono

Research output: Contribution to journalArticle

Abstract

Corynebacterium striatum, generally considered an opportunistic organism in humans, has recently been known to develop high-level daptomycin resistance (HLDR) shortly after drug exposure. To date, however, only several such clinical isolates have been described in the literature and clinical background of the resistant pathogen remains to be elucidated. Here, we report a case involving a C. striatum strain with HLDR harboring novel nucleotide mutations, together with a review of the relevant literature. To the best of our knowledge, this is the first well-investigated clinical report from Japan including a genetic investigation. Considering the rapid emergence of HLDR C. striatum in vitro experiment, there could be a number of underreporting cases. Scrupulous attention is required when administering daptomycin for the treatment of C. striatum infections, even if the organism has initially exhibited susceptibility.

Original languageEnglish
Pages (from-to)906-908
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 2019
Externally publishedYes

Keywords

  • Antimicrobial resistance
  • Corynebacterium
  • Daptomycin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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