Background variables for the patients with invasive bladder cancer suitable for bladder-preserving therapy

Naoto Miyanaga, Hideyuki Akaza, Shiro Hinotsu, Akira Joraku, Takehiro Oikawa, Noritoshi Sekido, Koji Kawai, Toru Shimazui

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Abstract

Objective: The present study was undertaken to identify the patients suitable for bladder preservation by analysis of our data. Methods: The subjects of this study were all 72 patients with T2-3N0M0 bladder cancer who underwent bladder-preserving therapy in our institute. The therapy involved intra-arterial chemotherapy with MTX and CDDP and concomitant radiotherapy. Results: Of the evaluable 70 cases, complete response (CR) was confirmed in 57 cases (81.4%). Among 56 bladder preserved cases, 47 (83.9%) preserved their functioning bladder, and 9 underwent salvage radical cystectomy at the following period. The median follow-up was 45.3 months. The 5-year cause-specific survival rate was 81% and the 5-year overall survival rate was 66%. On the basis of the results of univariate analysis, variables contributing to CR were selected. In T2, tumor size of ≤3 cm was scored 0 and >3 cm was scored 1, whereas single tumor was scored 0 and multiple were scored 1. In T3, tumor size of ≤3 cm was scored 0 and >3 cm was scored 1, whereas G2 was scored 0 and G3 scored 1. The CR rates were 93.8, 92.6, and 62.9% for total scores of 0, 1, and 2, respectively (P = 0.003; score 0 or 1 versus 2). The overall survival rate was significantly higher in the former group (P = 0.003). Conclusion: Bladder-preserving therapy can be acceptable for cases of single T2N0M0 tumor with a size of ≤3 cm and for T3N0M0 cases with a tumor size of ≤3 cm.

Original languageEnglish
Pages (from-to)852-857
Number of pages6
JournalJapanese journal of clinical oncology
Volume37
Issue number11
DOIs
Publication statusPublished - Nov 1 2007

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Keywords

  • Bladder preservation
  • Chemotherapy
  • Invasive bladder cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Miyanaga, N., Akaza, H., Hinotsu, S., Joraku, A., Oikawa, T., Sekido, N., Kawai, K., & Shimazui, T. (2007). Background variables for the patients with invasive bladder cancer suitable for bladder-preserving therapy. Japanese journal of clinical oncology, 37(11), 852-857. https://doi.org/10.1093/jjco/hym129