B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma without mediastinal disease: Mimicking nodular sclerosis classical Hodgkin lymphoma

Noriko Iwaki, Yasuharu Sato, Toshiro Kurokawa, Yoshinobu Maeda, Kyotaro Ohno, Mai Takeuchi, Katsuyoshi Takata, Yorihisa Orita, Shinji Nakao, Tadashi Yoshino

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma (BCLu-DLBCL/CHL), also known as gray-zone lymphoma, has overlapping clinical and biological characteristics of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma (CHL). These lymphomas are typically associated with mediastinal disease, and extranodal involvement is rare. In the present report, we describe a case of a 78-year-old woman with BCLu-DLBCL/CHL found to have extranodal lesions and no evidence of mediastinal disease. Although biopsy specimens were histologically similar to nodular sclerosis CHL, the tumor cells were positive for CD30 and mature B-cell markers, such as CD20, CD79a, PAX5, BOB.1, and OCT-2, but negative for CD15. Furthermore, the patient had extranodal lesions and an increased level of soluble IL-2 receptor. These findings are unusual in CHL. Therefore, we diagnosed the patient with BCLu-DLBCL/CHL. She received adriamycin, bleomycin, vincristine, and dacarbazine therapy and exhibited partial response. Some cases without mediastinal disease, such as our case, have been reported; however, these cases are rare and further studies are required.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalMedical Molecular Morphology
Volume46
Issue number3
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Diffuse large B-cell lymphoma
  • Gray-zone lymphoma
  • Immunohistochemistry
  • Nodular sclerosis classical Hodgkin lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology

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