Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development

Seiichi Koike, Yoshifumi Yutoh, Kazuko Keino-Masu, Sumihare Noji, Masayuki Masu, Hideyo Ohuchi

Research output: Contribution to journalArticle

25 Citations (Scopus)


Autotaxin (ATX) is a lysophospholipid-generating exoenzyme expressed in embryonic and adult neural tissues. We previously showed that ATX is expressed in the neural organizing centers, anterior head process, and midbrain-hindbrain boundary (MHB). To elucidate the role of ATX during neural development, here we examined the neural phenotypes of ATX-deficient mice. Expression analysis of neural marker genes revealed that lateral expansion of the rostral forebrain is reduced and establishment of the MHB is compromised as early as the late headfold stage in ATX mutant embryos. Moreover, ATX mutant embryos fail to complete cranial neural tube closure. These results indicate that ATX is essential for cranial neurulation and MHB establishment.

Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalDevelopmental Dynamics
Issue number2
Publication statusPublished - Feb 1 2011
Externally publishedYes



  • ATX
  • Anterior head process
  • Autotaxin
  • Enpp2
  • Knockout mouse
  • MHB
  • Midbrain-hindbrain boundary
  • Neural tube closure
  • Notochord

ASJC Scopus subject areas

  • Developmental Biology

Cite this