TY - JOUR
T1 - Autophagy as a potential mechanism underlying the biological effect of 1,25-Dihydroxyvitamin D3 on periodontitis
T2 - a narrative review
AU - Chen, Xiaoting
AU - Arias, Zulema
AU - Omori, Kazuhiro
AU - Yamamoto, Tadashi
AU - Shinoda-Ito, Yuki
AU - Takashiba, Shogo
N1 - Funding Information:
The authors acknowledge the use of Servier Medical Art as Figs. 1 , 2 , 3 and 4 were partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 Unported License.
Funding Information:
The financial support received from ISRO-Cell, Savitribai Phule Pune University (Project No. GOI-A-337(B) 129), Government of India is thankfully acknowledged. Thanks are due to the reviewer for his critical review and valuable suggestions. The authors (MAH and PBK) are thankful to the Head, Department of Geology, Savitribai Phule Pune University, Pune for extending all the facilities.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - The major active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D3), is known for its wide bioactivity in periodontal tissues. Although the exact mechanisms underlying its protective action against periodontitis remain unclear, recent studies have shown that 1,25D3 regulates autophagy. Autophagy is vital for intracellular pathogen invasion control, inflammation regulation, and bone metabolic balance in periodontal tissue homeostasis, and its regulation could be an interesting pathway for future periodontal studies. Since vitamin D deficiency is a worldwide health problem, its role as a potential regulator of autophagy provides new insights into periodontal diseases. Based on this premise, this narrative literature review aimed to investigate the possible connection between 1,25D3 and autophagy in periodontitis. A comprehensive literature search was conducted on PubMed using the following keywords (e.g., vitamin D, autophagy, periodontitis, pathogens, epithelial cells, immunity, inflammation, and bone loss). In this review, the latest studies on the protective action of 1,25D3 against periodontitis and the regulation of autophagy by 1,25D3 are summarized, and the potential role of 1,25D3-activated autophagy in the pathogenesis of periodontitis is analyzed. 1,25D3 can exert a protective effect against periodontitis through different signaling pathways in the pathogenesis of periodontitis, and at least part of this regulatory effect is achieved through the activation of the autophagic response. This review will help clarify the relationship between 1,25D3 and autophagy in the homeostasis of periodontal tissues and provide perspectives for researchers to optimize prevention and treatment strategies in the future.
AB - The major active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D3), is known for its wide bioactivity in periodontal tissues. Although the exact mechanisms underlying its protective action against periodontitis remain unclear, recent studies have shown that 1,25D3 regulates autophagy. Autophagy is vital for intracellular pathogen invasion control, inflammation regulation, and bone metabolic balance in periodontal tissue homeostasis, and its regulation could be an interesting pathway for future periodontal studies. Since vitamin D deficiency is a worldwide health problem, its role as a potential regulator of autophagy provides new insights into periodontal diseases. Based on this premise, this narrative literature review aimed to investigate the possible connection between 1,25D3 and autophagy in periodontitis. A comprehensive literature search was conducted on PubMed using the following keywords (e.g., vitamin D, autophagy, periodontitis, pathogens, epithelial cells, immunity, inflammation, and bone loss). In this review, the latest studies on the protective action of 1,25D3 against periodontitis and the regulation of autophagy by 1,25D3 are summarized, and the potential role of 1,25D3-activated autophagy in the pathogenesis of periodontitis is analyzed. 1,25D3 can exert a protective effect against periodontitis through different signaling pathways in the pathogenesis of periodontitis, and at least part of this regulatory effect is achieved through the activation of the autophagic response. This review will help clarify the relationship between 1,25D3 and autophagy in the homeostasis of periodontal tissues and provide perspectives for researchers to optimize prevention and treatment strategies in the future.
KW - Alveolar bone loss
KW - Autophagy
KW - Epithelial barrier
KW - Immunity
KW - Inflammation
KW - Periodontitis
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85147924991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85147924991&partnerID=8YFLogxK
U2 - 10.1186/s12903-023-02802-9
DO - 10.1186/s12903-023-02802-9
M3 - Review article
C2 - 36782172
AN - SCOPUS:85147924991
SN - 1472-6831
VL - 23
JO - BMC Oral Health
JF - BMC Oral Health
IS - 1
M1 - 90
ER -