Autologous transplantation of the internal limiting membrane for refractory macular holes

Yuki Morizane, Fumio Shiraga, Shuhei Kimura, Mio Hosokawa, Yusuke Shiode, Tetsuhiro Kawata, Mika Hosogi, Yukari Shirakata, Toshio Okanouchi

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Purpose To determine the effectiveness of autologous transplantation of the internal limiting membrane (ILM) for refractory macular holes. Design Prospective, interventional case series. Patient and Methods Ten eyes of 10 consecutive patients who underwent autologous transplantation of the ILM for the treatment of refractory macular holes were studied. The primary diseases in these patients were large idiopathic macular holes that had existed for more than 1 year (4 eyes), a traumatic macular hole (1 eye), myopic foveoschisis (2 eyes), foveoschisis resulting from pit-macular syndrome (2 eyes), and proliferative diabetic retinopathy (1 eye). Apart from the 5 eyes with idiopathic or traumatic macular holes, macular holes developed in the other 5 eyes after initial vitrectomies with ILM removal. In all eyes, regular macular hole surgery failed to achieve closure. The main outcome measures used in this study were macular hole closure and best-corrected visual acuity (BCVA). Results Macular holes were closed successfully in 9 eyes (90%) after autologous transplantation of the ILM. The postoperative BCVAs were significantly better than the preoperative BCVAs (P =.007, paired t test). Postoperative BCVAs improved by more than 0.2 logarithm of the minimal angle of resolution units in 8 eyes (80%) and were unchanged in 2 eyes (20%). Conclusions Although this is a pilot study, the results suggest that autologous transplantation of the ILM may contribute to improved anatomic and visual outcomes in the treatment of refractory macular holes and may warrant further investigation.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume157
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Retinal Perforations
Autologous Transplantation
Membranes
Vitrectomy
Diabetic Retinopathy
Visual Acuity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Autologous transplantation of the internal limiting membrane for refractory macular holes. / Morizane, Yuki; Shiraga, Fumio; Kimura, Shuhei; Hosokawa, Mio; Shiode, Yusuke; Kawata, Tetsuhiro; Hosogi, Mika; Shirakata, Yukari; Okanouchi, Toshio.

In: American Journal of Ophthalmology, Vol. 157, No. 4, 2014.

Research output: Contribution to journalArticle

@article{009ccc620eea4c32975a867e8f706802,
title = "Autologous transplantation of the internal limiting membrane for refractory macular holes",
abstract = "Purpose To determine the effectiveness of autologous transplantation of the internal limiting membrane (ILM) for refractory macular holes. Design Prospective, interventional case series. Patient and Methods Ten eyes of 10 consecutive patients who underwent autologous transplantation of the ILM for the treatment of refractory macular holes were studied. The primary diseases in these patients were large idiopathic macular holes that had existed for more than 1 year (4 eyes), a traumatic macular hole (1 eye), myopic foveoschisis (2 eyes), foveoschisis resulting from pit-macular syndrome (2 eyes), and proliferative diabetic retinopathy (1 eye). Apart from the 5 eyes with idiopathic or traumatic macular holes, macular holes developed in the other 5 eyes after initial vitrectomies with ILM removal. In all eyes, regular macular hole surgery failed to achieve closure. The main outcome measures used in this study were macular hole closure and best-corrected visual acuity (BCVA). Results Macular holes were closed successfully in 9 eyes (90{\%}) after autologous transplantation of the ILM. The postoperative BCVAs were significantly better than the preoperative BCVAs (P =.007, paired t test). Postoperative BCVAs improved by more than 0.2 logarithm of the minimal angle of resolution units in 8 eyes (80{\%}) and were unchanged in 2 eyes (20{\%}). Conclusions Although this is a pilot study, the results suggest that autologous transplantation of the ILM may contribute to improved anatomic and visual outcomes in the treatment of refractory macular holes and may warrant further investigation.",
author = "Yuki Morizane and Fumio Shiraga and Shuhei Kimura and Mio Hosokawa and Yusuke Shiode and Tetsuhiro Kawata and Mika Hosogi and Yukari Shirakata and Toshio Okanouchi",
year = "2014",
doi = "10.1016/j.ajo.2013.12.028",
language = "English",
volume = "157",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Autologous transplantation of the internal limiting membrane for refractory macular holes

AU - Morizane, Yuki

AU - Shiraga, Fumio

AU - Kimura, Shuhei

AU - Hosokawa, Mio

AU - Shiode, Yusuke

AU - Kawata, Tetsuhiro

AU - Hosogi, Mika

AU - Shirakata, Yukari

AU - Okanouchi, Toshio

PY - 2014

Y1 - 2014

N2 - Purpose To determine the effectiveness of autologous transplantation of the internal limiting membrane (ILM) for refractory macular holes. Design Prospective, interventional case series. Patient and Methods Ten eyes of 10 consecutive patients who underwent autologous transplantation of the ILM for the treatment of refractory macular holes were studied. The primary diseases in these patients were large idiopathic macular holes that had existed for more than 1 year (4 eyes), a traumatic macular hole (1 eye), myopic foveoschisis (2 eyes), foveoschisis resulting from pit-macular syndrome (2 eyes), and proliferative diabetic retinopathy (1 eye). Apart from the 5 eyes with idiopathic or traumatic macular holes, macular holes developed in the other 5 eyes after initial vitrectomies with ILM removal. In all eyes, regular macular hole surgery failed to achieve closure. The main outcome measures used in this study were macular hole closure and best-corrected visual acuity (BCVA). Results Macular holes were closed successfully in 9 eyes (90%) after autologous transplantation of the ILM. The postoperative BCVAs were significantly better than the preoperative BCVAs (P =.007, paired t test). Postoperative BCVAs improved by more than 0.2 logarithm of the minimal angle of resolution units in 8 eyes (80%) and were unchanged in 2 eyes (20%). Conclusions Although this is a pilot study, the results suggest that autologous transplantation of the ILM may contribute to improved anatomic and visual outcomes in the treatment of refractory macular holes and may warrant further investigation.

AB - Purpose To determine the effectiveness of autologous transplantation of the internal limiting membrane (ILM) for refractory macular holes. Design Prospective, interventional case series. Patient and Methods Ten eyes of 10 consecutive patients who underwent autologous transplantation of the ILM for the treatment of refractory macular holes were studied. The primary diseases in these patients were large idiopathic macular holes that had existed for more than 1 year (4 eyes), a traumatic macular hole (1 eye), myopic foveoschisis (2 eyes), foveoschisis resulting from pit-macular syndrome (2 eyes), and proliferative diabetic retinopathy (1 eye). Apart from the 5 eyes with idiopathic or traumatic macular holes, macular holes developed in the other 5 eyes after initial vitrectomies with ILM removal. In all eyes, regular macular hole surgery failed to achieve closure. The main outcome measures used in this study were macular hole closure and best-corrected visual acuity (BCVA). Results Macular holes were closed successfully in 9 eyes (90%) after autologous transplantation of the ILM. The postoperative BCVAs were significantly better than the preoperative BCVAs (P =.007, paired t test). Postoperative BCVAs improved by more than 0.2 logarithm of the minimal angle of resolution units in 8 eyes (80%) and were unchanged in 2 eyes (20%). Conclusions Although this is a pilot study, the results suggest that autologous transplantation of the ILM may contribute to improved anatomic and visual outcomes in the treatment of refractory macular holes and may warrant further investigation.

UR - http://www.scopus.com/inward/record.url?scp=84896084124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896084124&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2013.12.028

DO - 10.1016/j.ajo.2013.12.028

M3 - Article

C2 - 24418265

AN - SCOPUS:84896084124

VL - 157

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 4

ER -