Autoimmunity, infectious immunity, and atherosclerosis

Eiji Matsuura, Kazuko Kobayashi, Yukana Matsunami, Lianhua Shen, Nanhu Quan, Marina Makarova, Sergey V. Suchkov, Kiyoshi Ayada, Keiji Oguma, Luis R. Lopez

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Introduction: Vascular inflammation is common in certain systemic autoimmune diseases and contributes to the oxidation of low-density lipoprotein (oxLDL) and oxLDL/β2-glycoprotein I (β2GPI) complex formation. These complexes have been implicated as proatherogenic autoantigens that participate in the development of atherosclerotic disease. Discussion: We have demonstrated that the in vitro macrophage uptake of oxLDL/β2GPI complexes increases in the presence of IgG anti-β2GPI antibodies and that IgG immune complexes containing oxLDL/β2GPI upregulate the expression of both scavenger and Fcγ receptors to activate β2GPI-specific T cells. Some persistent infections may cause immune responses that promote atherogenesis. Cellular immunity (Th1) against Helicobacter pylori (H. pylori) derived heat shock protein 60 (Hp-HSP60) cross-reacts with endogenous HSP60 to cause cardiovascular disease likely by molecular mimicry. Conclusion: Infectious cellular response may be proatherogenic, while the humoral response (antibody production) may be protective. We review the recent progress in our understanding of autoimmunity and infectious immunity that promote atherosclerosis.

Original languageEnglish
Pages (from-to)714-721
Number of pages8
JournalJournal of Clinical Immunology
Volume29
Issue number6
DOIs
Publication statusPublished - Nov 2009

Fingerprint

Autoimmunity
Immunity
Atherosclerosis
Glycoproteins
LDL Lipoproteins
Chaperonin 60
Molecular Mimicry
Scavenger Receptors
Fc Receptors
Autoantigens
Antigen-Antibody Complex
Helicobacter pylori
Cellular Immunity
Autoimmune Diseases
Antibody Formation
Blood Vessels
Cardiovascular Diseases
Up-Regulation
Immunoglobulin G
Macrophages

Keywords

  • β2-glycoprotein I (β2GPI)
  • Atherosclerosis
  • Autoimmunity
  • Heat shock protein 60 (HSP60)
  • Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Autoimmunity, infectious immunity, and atherosclerosis. / Matsuura, Eiji; Kobayashi, Kazuko; Matsunami, Yukana; Shen, Lianhua; Quan, Nanhu; Makarova, Marina; Suchkov, Sergey V.; Ayada, Kiyoshi; Oguma, Keiji; Lopez, Luis R.

In: Journal of Clinical Immunology, Vol. 29, No. 6, 11.2009, p. 714-721.

Research output: Contribution to journalArticle

Matsuura, E, Kobayashi, K, Matsunami, Y, Shen, L, Quan, N, Makarova, M, Suchkov, SV, Ayada, K, Oguma, K & Lopez, LR 2009, 'Autoimmunity, infectious immunity, and atherosclerosis', Journal of Clinical Immunology, vol. 29, no. 6, pp. 714-721. https://doi.org/10.1007/s10875-009-9333-5
Matsuura, Eiji ; Kobayashi, Kazuko ; Matsunami, Yukana ; Shen, Lianhua ; Quan, Nanhu ; Makarova, Marina ; Suchkov, Sergey V. ; Ayada, Kiyoshi ; Oguma, Keiji ; Lopez, Luis R. / Autoimmunity, infectious immunity, and atherosclerosis. In: Journal of Clinical Immunology. 2009 ; Vol. 29, No. 6. pp. 714-721.
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