Abstract
Summary. Male (NZW × BXSB)F1 mice spontaneously develop a disease which closely resembles human systemic autoimmune disease, involving idiopathic thrombocytopenic purpura and glomerulonephritis. We investigated whether autoimmune thrombocytopenia in the mice responded to deoxyspergualin, as immunosuppressant. Deoxyspergualin completely prevented the development of thrombocytopenia and suppressed the increase in circulating autoantibodies against platelets. This agent also ameliorated lupus nephritis. These findings suggest that deoxyspergualin may be effective in the prevention of idiopathic thrombocytopenic purpura.
| Original language | English |
|---|---|
| Pages (from-to) | 691-696 |
| Number of pages | 6 |
| Journal | British Journal of Haematology |
| Volume | 91 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Nov 1995 |
| Externally published | Yes |
Keywords
- anti‐platelet antibodies
- deoxyspergulin
- idiopathic thrombocytopenic purpura
- immunosuppression
- mouse models
ASJC Scopus subject areas
- Hematology
Fingerprint Dive into the research topics of 'Autoimmune‐prone (NZW × BXSB)F<sub>1</sub> (W/BF<sub>1</sub>) mice escape severe thrombocytopenia after treatment with deoxyspergualin, an immunosuppressant'. Together they form a unique fingerprint.
Cite this
Nemoto, K., Mae, T., Saiga, K., Matsuura, E., & Koike, T. (1995). Autoimmune‐prone (NZW × BXSB)F1 (W/BF1) mice escape severe thrombocytopenia after treatment with deoxyspergualin, an immunosuppressant. British Journal of Haematology, 91(3), 691-696. https://doi.org/10.1111/j.1365-2141.1995.tb05370.x