Autoimmune‐prone (NZW × BXSB)F1 (W/BF1) mice escape severe thrombocytopenia after treatment with deoxyspergualin, an immunosuppressant

Kyuichi Nemoto, Takako Mae, Kan Saiga, Eiji Matsuura, Takao Koike

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Summary. Male (NZW × BXSB)F1 mice spontaneously develop a disease which closely resembles human systemic autoimmune disease, involving idiopathic thrombocytopenic purpura and glomerulonephritis. We investigated whether autoimmune thrombocytopenia in the mice responded to deoxyspergualin, as immunosuppressant. Deoxyspergualin completely prevented the development of thrombocytopenia and suppressed the increase in circulating autoantibodies against platelets. This agent also ameliorated lupus nephritis. These findings suggest that deoxyspergualin may be effective in the prevention of idiopathic thrombocytopenic purpura.

Original languageEnglish
Pages (from-to)691-696
Number of pages6
JournalBritish Journal of Haematology
Volume91
Issue number3
DOIs
Publication statusPublished - Nov 1995
Externally publishedYes

Keywords

  • anti‐platelet antibodies
  • deoxyspergulin
  • idiopathic thrombocytopenic purpura
  • immunosuppression
  • mouse models

ASJC Scopus subject areas

  • Hematology

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