Autoimmune responses as assessed by hypergammaglobulinemia and the presence of autoantibodies in patients with chronic hepatitis C.

H. Kawamoto, K. Sakaguchi, Akinobu Takaki, S. Ogawa, T. Tsuji

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We investigated autoimmunity, as assessed by hypergammaglobulinemia and the presence of autoantibodies including anti-nuclear antibodies (ANA) and anti-liver membrane antibodies (LMA), in 149 patients with chronic hepatitis C, 55 patients with chronic hepatitis B and 11 patients with autoimmune hepatitis. There was no significant difference in the incidence of these autoantibodies between chronic hepatitis C and chronic hepatitis B. Nine patients with chronic hepatitis C satisfied the serological criteria of autoimmune hepatitis (ANA positive and gammaglobulin or serum IgG greater than 2500 mg/dl), but none of the patients with chronic hepatitis B met the criteria. This suggests that autoimmunity is greater in chronic hepatitis C than in chronic hepatitis B. Of the 9 patients with chronic hepatitis C, all 4 patients tested for human leukocyte antigen (HLA) phenotype had HLA-DR4, which is known to be associated with autoimmune hepatitis in Japanese patients. We believe that hepatitis C virus (HCV) infection enhances the initiation and perpetuation of autoimmunity in susceptible individuals.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalActa Medica Okayama
Volume47
Issue number5
Publication statusPublished - Oct 1993

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Hypergammaglobulinemia
Chronic Hepatitis C
HLA Antigens
Autoimmunity
Autoantibodies
Antibodies
Chronic Hepatitis B
Viruses
Liver
Autoimmune Hepatitis
Anti-Idiotypic Antibodies
Immunoglobulin G
Membranes
Virus Diseases
Hepacivirus
Phenotype
Incidence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Autoimmune responses as assessed by hypergammaglobulinemia and the presence of autoantibodies in patients with chronic hepatitis C. / Kawamoto, H.; Sakaguchi, K.; Takaki, Akinobu; Ogawa, S.; Tsuji, T.

In: Acta Medica Okayama, Vol. 47, No. 5, 10.1993, p. 305-310.

Research output: Contribution to journalArticle

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