Autoimmune hemolytic anemia in allergic granulomatous angitis (Churg-Strauss syndrome)

Kensuke Kojima, Eijiro Omoto, Yoshio Katayama, Masatoshi Uno, Ichiro Takada, Goro Kimura, Arihiko Kanehiro, Shinya Tada, Kyoichi Hayashi, Ikuro Kimura, Hiroshi Sanada, Mine Harada

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We describe a patient with allergic granulomatous angitis who developed autoimmune hemolytic anemia (AIHA). A 44-year-old male had been suffering from bronchial asthma. On admission, laboratory tests revealed the presence of severe eosinophilia (21500/μl), elevation of total immunoglobulin E (IgE), high lactic dehydrogenase (LDH) and low haptoglobin levels, in addition to moderate reticulocytosis. During admission, the patient showed almost simultaneous occurrence of vasculitis in the extremities, severe hemolysis and exacerbation of asthma in relation to the progression of eosinophilia. Both IgM and IgG autoantibodies were considered to be responsible for hemolysis. Interestingly, serum levels of interleukin-4 (IL-4) and IL-5 were increased in association with eosinophilia and increased IgE production. These findings suggest that the AIHA in this patient is mediated or enhanced at least partly by high IL-4 and IL-5 production. Although AIHA in this syndrome is very rare, it should be considered as a clinical manifestation.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalInternational journal of hematology
Volume63
Issue number2
DOIs
Publication statusPublished - Feb 1996

Keywords

  • IL-4
  • IL-5
  • T lymphocyte
  • eosinophil
  • eosinophil cationic protein

ASJC Scopus subject areas

  • Hematology

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