Autoantigen and molecular chaperone in rheumatoid arthritis--their roles in metabolism of chondrocytes

Research output: Contribution to journalArticle

Abstract

The endoplasmic reticulum chaperone; heat shock protein/rheumatoid arthritis-related antigen (HSP47/RA-A47), in addition to its important intercellular functions for collagen maturation and secretion, has chondrocytes-destructive roles such as induction of endoplasmic reticulum (ER)-stress and metabolic gene expressions result in apoptosis when HSP47/RA-A47 is downregulated. Extracellular HSP47/RA-A47 may act as an autoantigen, but also regulate autoimmune inflammation. It is, therefore, a potential new biologic therapy for rheumatoid arthritis.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalClinical calcium
Volume16
Issue number9
Publication statusPublished - Sep 2006

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Molecular Chaperones
Autoantigens
Chondrocytes
Rheumatoid Arthritis
Biological Therapy
Endoplasmic Reticulum Stress
Heat-Shock Proteins
Endoplasmic Reticulum
Collagen
Down-Regulation
Apoptosis
Inflammation
Gene Expression
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "The endoplasmic reticulum chaperone; heat shock protein/rheumatoid arthritis-related antigen (HSP47/RA-A47), in addition to its important intercellular functions for collagen maturation and secretion, has chondrocytes-destructive roles such as induction of endoplasmic reticulum (ER)-stress and metabolic gene expressions result in apoptosis when HSP47/RA-A47 is downregulated. Extracellular HSP47/RA-A47 may act as an autoantigen, but also regulate autoimmune inflammation. It is, therefore, a potential new biologic therapy for rheumatoid arthritis.",
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