Augmentation of cytotoxicity of tumor-infiltrating lymphocytes by biological response modifiers

Gotoh Kiyotoshi Gotoh, Gouchi Akira Gouchi, Akura Yosikazu Akura, Tanaka Noriaki Tanaka, Orita Kunzo Orita

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Lymphocyte infiltration into a tumor has been regarded as an expression of host immunity against cancer, but tumor-infiltrating lymphocytes (TIL) have little or no cytotoxicity. This study examined two different approaches to augment this low cytotoxicity. Firstly, biological response modifiers (OK-432, PSK) were injected into gastric cancer intralesionally. Intralesional injection of OK-432 or PSK significantly augmented the cytotoxicity of TIL. By the injection of OK-432, the ratio of OKT8-, Leu7-positive cells were increased in the TIL subset. In the second approach, TIL of gastric or pulmonary cancer patients were cultured with interleukin-2 (IL-2) in vitro. Co-culturing with IL-2 augmented the low cytotoxicity of TIL, and broad-reactive lymphokine-activated killer (LAK) cells were generated from TIL.

Original languageEnglish
Pages (from-to)485-492
Number of pages8
JournalInternational Journal of Immunopharmacology
Volume13
Issue number5
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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