Augmentation index is associated with B-type natriuretic peptide in patients with paroxysmal atrial fibrillation

Youko Kaji, Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Shigeshi Kamikawa, Kosuke Sakane, Tomoki Kitawaki, Shozo Kusachi, Kengo Fukushima Kusano, Hiroshi Itoh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

B-type natriuretic peptide (BNP) levels have been shown to be elevated in patients with paroxysmal atrial fibrillation (PAF); however, the underlying mechanisms have not been fully elucidated. Earlier, we reported that an increase in the augmentation index (AI), which is an index of wave reflection and arterial stiffness, is associated with PAF. In this study, we investigate the relationship between the BNP level and AI in patients with PAF. We enrolled 92 patients with a history of PAF and 90 age- and gender-matched individuals without PAF. AI was calculated using applanation tonometry of the radial artery when all patients were on sinus rhythm. Plasma BNP levels were measured simultaneously. An arterial stiffness parameter, the cardio-ankle vascular index (CAVI), was also evaluated. The increased AI in patients with PAF correlated with the elevation of the BNP level (r=0.47, P

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalHypertension Research
Volume32
Issue number7
DOIs
Publication statusPublished - 2009

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Brain Natriuretic Peptide
Atrial Fibrillation
Vascular Stiffness
Radial Artery
Manometry
Ankle
Blood Vessels

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Augmentation index is associated with B-type natriuretic peptide in patients with paroxysmal atrial fibrillation. / Kaji, Youko; Miyoshi, Toru; Doi, Masayuki; Hirohata, Satoshi; Kamikawa, Shigeshi; Sakane, Kosuke; Kitawaki, Tomoki; Kusachi, Shozo; Kusano, Kengo Fukushima; Itoh, Hiroshi.

In: Hypertension Research, Vol. 32, No. 7, 2009, p. 611-616.

Research output: Contribution to journalArticle

Kaji, Youko ; Miyoshi, Toru ; Doi, Masayuki ; Hirohata, Satoshi ; Kamikawa, Shigeshi ; Sakane, Kosuke ; Kitawaki, Tomoki ; Kusachi, Shozo ; Kusano, Kengo Fukushima ; Itoh, Hiroshi. / Augmentation index is associated with B-type natriuretic peptide in patients with paroxysmal atrial fibrillation. In: Hypertension Research. 2009 ; Vol. 32, No. 7. pp. 611-616.
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AU - Kamikawa, Shigeshi

AU - Sakane, Kosuke

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