Augmentation in cytotoxicity of lymphnode lymphocytes by OK-432

Noriaki Tanaka, Kiyotoshi Gotoh, Genso Kobayashi, Akira Gouchi, Kunzo Orita

Research output: Contribution to journalArticle

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Abstract

It has been demonstrated that natural killer (NK) cell activity of lymphnode lymphocytes (LNL) is very low and hardly augmented by interferon. In this study, OK-432 was injected into the gastric cancer mass through endoscopy one week before the operation, through which NK activity of LNL was significantly increased. A single cell assay could divide the OK-432-injected patients into two groups; responder and non-responder. In responders, the increased activity induced by OK-432 was found also in the distal lymphnodes.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalInternational Journal of Immunopharmacology
Volume16
Issue number2
DOIs
Publication statusPublished - 1994

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Picibanil
Lymphocytes
Natural Killer Cells
Interferons
Endoscopy
Stomach Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Augmentation in cytotoxicity of lymphnode lymphocytes by OK-432. / Tanaka, Noriaki; Gotoh, Kiyotoshi; Kobayashi, Genso; Gouchi, Akira; Orita, Kunzo.

In: International Journal of Immunopharmacology, Vol. 16, No. 2, 1994, p. 131-135.

Research output: Contribution to journalArticle

Tanaka, Noriaki ; Gotoh, Kiyotoshi ; Kobayashi, Genso ; Gouchi, Akira ; Orita, Kunzo. / Augmentation in cytotoxicity of lymphnode lymphocytes by OK-432. In: International Journal of Immunopharmacology. 1994 ; Vol. 16, No. 2. pp. 131-135.
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