Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message

Akihiko Azuma, Hiroyuki Miyachi, Yoshihiro Shibata, Yuichi Hashimoto, Shigeo Iwasaki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

N(α)-Phthalimidoglutarimide (thalidomide), 2-(2,6-diisopropylphenyl)- 1H-iso-indole-1,3-dione (PP-33) and its 4,5,6,7-tetrafluoro derivative (FPP- 33) augmented 12-O-tetradecanoylphorbol 13-acetate-induced production by human leukemia HL-60 cells of both tumor necrosis factor alpha (TNF-α) mRNA and secreted TNF-α protein. Intracellular TNF-α protein production was increased to a lesser extent.

Original languageEnglish
Pages (from-to)1001-1003
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume19
Issue number7
Publication statusPublished - Jul 1996
Externally publishedYes

Fingerprint

Phthalimides
Phorbol Esters
Tumor Necrosis Factor-alpha
Thalidomide
HL-60 Cells
Tetradecanoylphorbol Acetate
Leukemia
Proteins
Messenger RNA

Keywords

  • HL-60
  • phenylphthalimide
  • phorbol ester
  • thalidomide
  • tumor necrosis factor

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Azuma, A., Miyachi, H., Shibata, Y., Hashimoto, Y., & Iwasaki, S. (1996). Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message. Biological and Pharmaceutical Bulletin, 19(7), 1001-1003.

Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message. / Azuma, Akihiko; Miyachi, Hiroyuki; Shibata, Yoshihiro; Hashimoto, Yuichi; Iwasaki, Shigeo.

In: Biological and Pharmaceutical Bulletin, Vol. 19, No. 7, 07.1996, p. 1001-1003.

Research output: Contribution to journalArticle

Azuma, A, Miyachi, H, Shibata, Y, Hashimoto, Y & Iwasaki, S 1996, 'Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message', Biological and Pharmaceutical Bulletin, vol. 19, no. 7, pp. 1001-1003.
Azuma, Akihiko ; Miyachi, Hiroyuki ; Shibata, Yoshihiro ; Hashimoto, Yuichi ; Iwasaki, Shigeo. / Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message. In: Biological and Pharmaceutical Bulletin. 1996 ; Vol. 19, No. 7. pp. 1001-1003.
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