Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3

Koji Kamiya, Yumi Aoyama, Chie Wakashima, Tomoko Kudo, Kimiko Nakajima, Shigetoshi Sano, Norito Ishii, Kwesi Teye, Takashi Hashimoto, Keiji Iwatsuki, Yoshiki Tokura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In patients with pemphigus vulgaris (PV), pathogenic immunoglobulin (Ig)G antibodies are most commonly directed against desmoglein 3 (Dsg3). It has recently been reported, however, that IgG anti-desmocollin 3 (Dsc3) antibodies are detected in some cases of pemphigus with or without IgG anti-Dsg3 antibodies. We present a case of pemphigus with IgG antibodies against Dsg3 and Dsc3. Subsequent studies showed that the cell surface distribution pattern of Dsc3 but not Dsg3 was altered, suggesting that suprabasal acantholytic blisters were induced by IgG anti-Dsc3 antibodies rather than IgG anti-Dsg3 antibodies. Our case suggests that anti-Dsc3 antibodies may be pathogenic in cases positive for the dual cadherin autoantibodies.

Original languageEnglish
JournalJournal of Dermatology
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

Desmocollins
Desmoglein 3
Pemphigus
Autoantibodies
Immunoglobulin G
Antibodies
Cadherins
Blister
anti-IgG

Keywords

  • Desmocollin 3
  • Desmoglein 3
  • Immunoglobulin G autoantibodies
  • Immunostaining
  • Pemphigus

ASJC Scopus subject areas

  • Dermatology

Cite this

Kamiya, K., Aoyama, Y., Wakashima, C., Kudo, T., Nakajima, K., Sano, S., ... Tokura, Y. (Accepted/In press). Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3. Journal of Dermatology. https://doi.org/10.1111/1346-8138.13086

Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3. / Kamiya, Koji; Aoyama, Yumi; Wakashima, Chie; Kudo, Tomoko; Nakajima, Kimiko; Sano, Shigetoshi; Ishii, Norito; Teye, Kwesi; Hashimoto, Takashi; Iwatsuki, Keiji; Tokura, Yoshiki.

In: Journal of Dermatology, 2015.

Research output: Contribution to journalArticle

Kamiya, K, Aoyama, Y, Wakashima, C, Kudo, T, Nakajima, K, Sano, S, Ishii, N, Teye, K, Hashimoto, T, Iwatsuki, K & Tokura, Y 2015, 'Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3', Journal of Dermatology. https://doi.org/10.1111/1346-8138.13086
Kamiya, Koji ; Aoyama, Yumi ; Wakashima, Chie ; Kudo, Tomoko ; Nakajima, Kimiko ; Sano, Shigetoshi ; Ishii, Norito ; Teye, Kwesi ; Hashimoto, Takashi ; Iwatsuki, Keiji ; Tokura, Yoshiki. / Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3. In: Journal of Dermatology. 2015.
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AU - Kudo, Tomoko

AU - Nakajima, Kimiko

AU - Sano, Shigetoshi

AU - Ishii, Norito

AU - Teye, Kwesi

AU - Hashimoto, Takashi

AU - Iwatsuki, Keiji

AU - Tokura, Yoshiki

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