Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3

Koji Kamiya, Yumi Aoyama, Chie Wakashima, Tomoko Kudo, Kimiko Nakajima, Shigetoshi Sano, Norito Ishii, Kwesi Teye, Takashi Hashimoto, Keiji Iwatsuki, Yoshiki Tokura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In patients with pemphigus vulgaris (PV), pathogenic immunoglobulin (Ig)G antibodies are most commonly directed against desmoglein 3 (Dsg3). It has recently been reported, however, that IgG anti-desmocollin 3 (Dsc3) antibodies are detected in some cases of pemphigus with or without IgG anti-Dsg3 antibodies. We present a case of pemphigus with IgG antibodies against Dsg3 and Dsc3. Subsequent studies showed that the cell surface distribution pattern of Dsc3 but not Dsg3 was altered, suggesting that suprabasal acantholytic blisters were induced by IgG anti-Dsc3 antibodies rather than IgG anti-Dsg3 antibodies. Our case suggests that anti-Dsc3 antibodies may be pathogenic in cases positive for the dual cadherin autoantibodies.

Original languageEnglish
Pages (from-to)429-431
Number of pages3
JournalJournal of Dermatology
Volume43
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

Keywords

  • desmocollin 3
  • desmoglein 3
  • immunoglobulin G autoantibodies
  • immunostaining
  • pemphigus

ASJC Scopus subject areas

  • Dermatology

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    Kamiya, K., Aoyama, Y., Wakashima, C., Kudo, T., Nakajima, K., Sano, S., Ishii, N., Teye, K., Hashimoto, T., Iwatsuki, K., & Tokura, Y. (2016). Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3. Journal of Dermatology, 43(4), 429-431. https://doi.org/10.1111/1346-8138.13086