Attenuated sensory deprivation-induced changes of parvalbumin neuron density in the barrel cortex of fcyRIIB-def icient mice

Makiko Watanabe, Hiroshi Ueno, Shunsuke Suemitsu, Eriko Yokobayashi, Yousuke Matsumoto, Shinichi Usui, Hiroko Sujiura, Motoi Okamoto

Research output: Contribution to journalArticle

Abstract

Recent studies have demonstrated the important role of immune molecules in the development of neu-ronal circuitry and synaptic plasticity. We have detected the presence of FcyRllB protein in parvalbu-min-containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in FcyRllB-deflcient mice (FcyRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between FcyRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (PO) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from PO or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in Fey R11B-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that Fey R11B contributes to sensory experience-regulated expression of PV.

Original languageEnglish
Pages (from-to)143-154
Number of pages12
JournalActa Medica Okayama
Volume66
Issue number2
Publication statusPublished - 2012

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Sensory Deprivation
Parvalbumins
Neurons
Neuronal Plasticity
Interneurons
Plasticity
Parturition
Molecules

Keywords

  • Barrel cortex
  • Fast-spiking interneurons
  • FcyRllB
  • parvalbumin
  • Sensory deprivation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Attenuated sensory deprivation-induced changes of parvalbumin neuron density in the barrel cortex of fcyRIIB-def icient mice. / Watanabe, Makiko; Ueno, Hiroshi; Suemitsu, Shunsuke; Yokobayashi, Eriko; Matsumoto, Yousuke; Usui, Shinichi; Sujiura, Hiroko; Okamoto, Motoi.

In: Acta Medica Okayama, Vol. 66, No. 2, 2012, p. 143-154.

Research output: Contribution to journalArticle

Watanabe, Makiko ; Ueno, Hiroshi ; Suemitsu, Shunsuke ; Yokobayashi, Eriko ; Matsumoto, Yousuke ; Usui, Shinichi ; Sujiura, Hiroko ; Okamoto, Motoi. / Attenuated sensory deprivation-induced changes of parvalbumin neuron density in the barrel cortex of fcyRIIB-def icient mice. In: Acta Medica Okayama. 2012 ; Vol. 66, No. 2. pp. 143-154.
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