Atherogenic antiphospholipid antibodies in antiphospholipid syndrome

Research output: Chapter in Book/Report/Conference proceedingConference contribution

15 Citations (Scopus)

Abstract

Macrophage uptake of oxidized LDL (oxLDL) plays a critical role in early stages of atherosclerosis. We previously reported that oxLDL forms stable complexes with β2-glycoprotein I (β2GPI), and that these complexes were frequently present in the sera of patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). oxLDL/β2GPI complexes were shown to be antigenic targets for autoantibodies present in APS. To understand the role of autoantibodies in accelerated atherosclerosis of SLE and APS, we investigated the binding characteristics of β2GPI and oxLDL to mouse macrophages, and the effect of anti-β2GPI and anti-oxLDL autoantibodies on this macrophage binding. IgM anti-oxLDL antibody (derived from Apoe-/- mouse) showed inhibitory effect on oxLDL binding to macrophages. Although β2GPI partly inhibited oxLDL binding to macrophages, IgG anti-β2GPI autoantibody (derived from APS model mouse) showed pro-atherogenic property by promoting the binding of oxLDL/β2GPI to macrophages.

Original languageEnglish
Title of host publicationAutoimmunity, Part D
Subtitle of host publicationAutoimmune Disease, Annus Mirabilis
PublisherBlackwell Publishing Inc.
Pages489-496
Number of pages8
ISBN (Print)157331708X, 9781573317085
DOIs
Publication statusPublished - Jun 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1108
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Antiphospholipid syndrome
  • Oxidized low-density lipoprotein
  • β2-glycoprotein I

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Kobayashi, K., Lopez, L. R., & Matsuura, E. (2007). Atherogenic antiphospholipid antibodies in antiphospholipid syndrome. In Autoimmunity, Part D: Autoimmune Disease, Annus Mirabilis (pp. 489-496). (Annals of the New York Academy of Sciences; Vol. 1108). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1422.052